Characterization of Powdered Drugs by UV Absorption Spectrum in the Hospital Pharmacy

概要

論文の詳細を見る
Characterization of powdered drugs depends on a visual inspection of the dispenser in most hospitals. And one of the most important problems of visual inspection is its lack of reliance that must be excluded from the actual preparation of the drug itself. In this study, we attempted to develop a method to resolve this problem using a quick and easy procedure presenting greater reliability than the currently applied visual one. Combining non-solvent sample preparation, opal glass absorption spectroscopy, baseline collection, the relative strengths of absorbance at three wavelengths (Qr values), and a computer system, we developed a method by which characterization of drugs can be done quickly and easily, even if the subject mixture contains 2-3 kinds of drugs. Characterization of drugs using the method has one principal defect, however, that it demands Qr values of pure components before use, unless s the characteriation of drugs can not be accomplished from the Qr plot. In spite of this fault, the Qr plot prepared by the method is useful for the characterization of drugs in a hospital pharmacy because even the calculation of the Qr plot or not the preparation is correct.
日本医療薬学会の論文
1997-02-10