Inhibitory Action of Oren-gedoku-to Extract on Enzymatic Lipid Peroxidation in Rat Liver Microsomes
スポンサーリンク
概要
- 論文の詳細を見る
We examined the inhibitory action of the extract of Oren-gedoku-to, a traditional herbal medicine known to act as an antioxidant, on enzymatic lipid peroxidation in rat liver microsomes. Simultaneous addition of a spraydried preparation of Oren-gedoku-to extract(Tsumura TJ-15)inhibited enzymatic lipid peroxidation induced by reduced β-nicotinamide adenine dinucleotide phosphate(NADPH)and ADP/Fe^<3+> complex in liver microsomes in a dose-dependent manner. When the inhibition by TJ-15 of enzymatic lipid peroxidation in liver microsomes was kinetically annlyzed, this medicine showed a competitive inhibition against NADPH or ADP/Fe^<3+> complex. TJ-15 inhibited the NADPH-driven enzymatic reduction of ADP/Fe^<3+> complex or cytochrome c in liver microsomes competitively. TJ-l5 enhanced NADPH consumption by liver microsomes with ADP/Fe^<3+> complex. Treatment with TJ-15 after the onset of enzymatic lipid peroxidation in liver microsomes inhibited the progression or lipid peroxidation in a dose-dependent manner. The present results indicate that Oren-gedoku-to extract inhibits enzymatic lipid peroxidation in rat liver microsomes in the initiation and propagation steps in a dose-dependent manner. These results also suggest that Oren-gedoku-to extract inhibits enzymatic lipid peroxidation in rat liver microsomes not only through its antioxidant action but also through reduction of the supply of electrons derived from NADPH to ADP/Fe^<3+> complex in liver microsomes both in a competitive manner and through stimulation of NADPH oxidation.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
-
OHTA Yoshiji
Department of Chemistry, Fujita Health University School of Medicine
-
HARADA Nobuhiro
Department of Electrical Engineering, Nagaoka University of Technology
-
Hayashi Takahiro
Department of Cardiology, Kinki University School of Medicine
-
HISHINUMA TAKANORI
Division of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University
-
Harada N
Department Of Electrical Engineering (nagaoka University Of Technology)
-
Harada N
Department Of Biochemistry Fujita Health University School Of Medicine
-
INAGAKI Shoji
Department of Pharmacy, Fujita Health University Hospital
-
Ohta Yoshiji
Department Of Chemistry Fujita Health University School Of Medicine
-
Ohta Yoshiji
Department Of Biochemistry School Of Medicine Fujita Health University
-
Harada Nobuhiro
Department Of Electrical Engineering (nagaoka University Of Technology)
-
Harada Nobuhiro
National Chemical Laboratory For Industry
-
Harada Nobuhiro
Department Of Biochemistry Fujita Health University
-
Hayashi T
Department Of Pharmacy Fujita Health University Hospital
-
Hayashi Takahiro
Department Of Cardiology Kinki University School Of Medicine
-
Inagaki Shoji
Department Of Pharmacy Fujita Health University Hospital
-
Inagaki Shoji
Department Of Hospital Pharmacy Mie University School Of Medicine
-
Hishinuma T
Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University
関連論文
- Colorectal Cancer and Serum C-reactive Protein Levels : a Case-control Study Nested in the JACC Study
- Formation and Expansion of Ablation Plasmas Produced by Pulsed Ion Beams for Thin Films Production
- PJ-307 Discrimination of Human Coronary Calcified Nodule by Angioscopy(Atherosclerosis, clinical-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-575 Von Willebrand Factor Cleaving Protease (ADAMTS13) Has Less Potent Activity at Acute Phase in Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical-8 (IHD) PJ97,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of t
- PE-121 Positive Remodeling of Culprit Lesion Precipitates In-stent Thrombus Following Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-6 (IHD) PE21,Poster Session (English),The 70th Anniversary Annual Scientific Meet
- OJ-293 Discrimination of Human Coronary Thrombus Types by Optical Coherence Tomography(Acute coronary syndrome, basic/clinical-3 (IHD) OJ49,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-230 Acute Myocardial Infarction with High Level of Remnant-like Lipoproteins Particles Cholesterol Has More Potent Vulnerable Plaques at the Culprit Lesion(Acute myocardial infarction, clinical (pathophysiology)-1 (IHD) OE39,Oral Presentation (English)
- OE-185 Serum Level of Remnant-like Lipoproteins Particles Cholesterol can be a Predictor of Vasospastic Angina Pectoris(Angina pectoris, basic/clinical-1 (IHD) OE31,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- OE-033 Amount of Thrombus in Culprit Lesion is in Proportion to Serum hs-CRP Level at 1 Month after Myocardial Infarction Onset(Acute myocardial infarction, clinical (diagnosis/treatment)-1 (IHD) OE6,Oral Presentation (English),The 70th Anniversary Annual
- Calcium Antagonists for Secondary Prevention of Myocardial Infarction : Is There a Need to Shift From Short-Acting to Long-Acting Types?
- Recent Decline in Hospital Mortality Among Patients With Acute Myocardial Infarction
- High Sensitive C-Reactive Protein Level Indicates Thrombus at the Culprit Lesion Following Acute Myocardial Infarction (Acute Myocardial Infarction, Clinical (Pathophysiology) 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society
- Higher Remnant-like Lipoproteins Particles Cholesterol Levels Make Plaques-thrombi Complex Volume Greater at the Culprit Lesion of Acute Myocardial Infarction (Acute Myocardial Infarction, Clinical (Pathophysiology) 7 (IHD), The 69th Annual Scientific Mee
- Valsartan Inhibits Coronary Intimal Hyperplasia after Directional Coronary Atherectomy (Restenosis after Angioplasty, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-342 Vascular Healing in the Culprit Lesion Following Acute Myocardial Infarction is Delayed by Positive Remodeling(Acute Myocardial Infarction, Clinical (Pathophysiology) 7 (IHD) : PE58)(Poster Session (English))
- OJ-410 Moderate alcohol consumption improved the prognosis on cardiovascular events in healed myocardial infarction younger than 65years but not in older(Preventive Medicine/Epidemiology/Education 3 (H) : OJ50)(Oral Presentation (Japanese))
- OE-170 Eroded Plaque Lesion Develops Myocardial Infarction in the Smaller Coronary Artery Compared with Ruptured Plaque Lesion(Intravascular Endoscopy/Intravascular Ultrasound 1 (I) : OE21)(Oral Presentation (English))
- Shigyakusan extract attenuates enhanced hepatic neutrophil infiltration and oxidative stress with progression of α-naphthylisothiocyanate-induced liver injury in rats
- The Nutrient Formula Containing Eicosapentaenoic Acid and Docosahexaenoic Acid Benefits the Fatty Acid Status of Patients Receiving Long-Term Enteral Nutrition
- Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli
- Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital
- Introduction to Pulse Power Producing Pulsed Ion-Beam Ablation Plasma for Propulsion Applications
- Fundamental Study of Pulsed Ion Beam Ablation Plasma Model for Space Propulsion Applications
- Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes
- PJ-384 Identification of Vascular Responses to Coronary Stenting by Optical CoherenceTomography : a Sub-analysis from the Japanese Multi-center Safety Trial(Intravascular endoscopy/Intravascular ultrasound-6, The 71st Annual Scientific Meeting of the Japa
- Effect of Oral Vitamin E Administration on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator(Pharmacology)
- Effect of Gefarnate on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator, in Comparison with That of Teprenone(Pharmacology)
- A Change in Gastric Mucosal Ascorbic Acid Status with the Formation, Progression, and Recovery of Compound 48/80-induced Acute Gastric Mucosal Lesions in Rats
- OE-050 Safety and Feasibility of a Novel Intravascular OCT Image Wire System in a Clinical Setting : Japanese multi-center Study(Intravascular endoscopy/Intravascular ultrasound-1 (I) OE9,Oral Presentation (English),The 70th Anniversary Annual Scientific
- PJ-210 Effects of Carperitide and Nitroglycerin on Renal Function in Patients with Acute Heart Failure(Heart failure, clinical-15 (M) PJ35,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Detection of Inflamed Plaques with Optical Coherence Tomography(Beyond Conventional Signal Analysis,Topic 5 (TP5) (I),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Cardiac Mortality in Women Compared with Men in Patients with Acute Myocardial Infarction
- PJ-145 Utility of exercise echocardiography using hand-carried cardiac ultrasound (HCU) device for diagnosing coronary artery diseases(Echo/Doppler 1 (I) : PJ24)(Poster Session (Japanese))
- Estrogen Secreting Adrenal Adenocarcinoma in an 18-Month-old Boy: Aromatase Activity, Protein Expression, mRNA and Utilization of Gonadal Type Promoter
- Valproic Acid Elimination Rate and Urinary Excretion of Its Glucuronide Conjugate in Patients with Epilepsy
- Urinary Metabolites of Valproic Acid in Epileptic Patients
- Continuous Long-Term Dosing with Oral Slow-Release Isosorbide Dinitrate Does not Reduce Incidence of Cardiac Events in Older Post-MI Patients
- Foil Acceleration of Double-Layer Target by Intense Pulsed Ion Beam Ablation(Instrumentation, Measurement, and Fabrication Technology)
- Foil Acceleration of Double Layer Target by Intense, Pulsed, Ion-Beam Ablation
- Development of a Numerical Tool for Foil Acceleration by an Intense Pulsed Ion Beam
- Non-Ruptured Eroded Plaque in the Culprit Lesion Develops Less Neointimal Proliferation after Stenting Compared with Ruptured Plaque
- Ischemia-Related Lesion Characteristics in Patients with Vasospastic Angina : Analysis by Angioscopy and Intravascular Ultrasound
- Clinical Differences of Ruptured Plaque and Non-Ruptured Plaque of Culprit Lesions in Patients with Unstable Angina Pectoris
- Drug Treatment for Secondary Prevention of Myocardial Infarction
- Simultaneous determination of pancuronium, vecuronium and their related compounds using LC-ESI-MS
- Determination of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) using LC-ESI-MS method and application to hemolyzed blood
- Incomplete Testicular Feminization Syndrome: Studies on Androgen Receptor(AR) Function, AR Gene Analysis, and Aromatase Activities at Puberty and Long-Term Observations of Clinical and Hormonal Features From Infancy to Puberty
- Inhibitory Action of Oren-gedoku-to Extract on Enzymatic Lipid Peroxidation in Rat Liver Microsomes
- MODE OF ACTION AND FUNCTIONAL SIGNIFICANCE OF ESTROGEN INDUCING THE GROWTH OF CEREBELLAR PURKINJE CELLS(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF THE ROLE OF ESTROGEN IN THE GROWTH OF CEREBELLAR PURKINJE CELLS USING AROMATASE-DEFICIENT MICE
- Midterm results of aortic valve replacement with Carpentier-Edwards porcine bioprosthesis
- P484 INFLUENCE OF ADAPTIVE REMODELING ON RESTENOSIS FOLLOWING ANGIOPLASTY
- P246 LIMITATIONS OF PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY (PTCA) WITH REFERENCE TO QUALITY OF LIFE(QOL) ON ANGINA PECTORIS : ASESSMENT BY MULTIVARIATE ANALYSIS
- -P387- Reevaluation of Percutaneous transluminal coronary angioplasty (PTCA) from a viewpoint of quality of life (QOL) on coronary artery disease(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0768- Assesement of the procedural outcome and the mechanism of restenosis of Directional Coronary Atherectomy by Intravascular Ultrasound(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- TO ASSESS THE CLINICAL USEFULNESS OF INTRAVASCULAR ULTRASOUND IN PERCUTANEOUS TRANSLUMIUNAL ANGIOPLASTY : TO DETERMINE THE ENDPOINT IN PTCA AND ASSESS THE NECHANISM OF RESTENOSIS
- ACCURACY AND DRAWBACKS OF THERMODILUTION METHOD IN MEASUREMENT OF RIGHT VENTRICULAR EJECTION FRACTION : STUDY OF SIMULTANEOUS MEASUREMENT WITH TWO THERMISTORS PLACED AT DIFFERENT REGIONS
- Possible Contribution of a Decrease in Serum Albumin Concentration to a Low Level of Blood L-Tryptophan in Nephrotic Rats
- Short-Term Ascorbic Acid Deficiency Does Not Impair Antioxidant Status in Lens of Guinea Pigs
- Fate of Elevated L-Tryptophan in the Blood of Nephrotic Rats with Oral L-Tryptophan Administration in Their Body
- Protective Effect of Teprenone Against Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats
- Protective Effect of Ebselen, a Seleno-Organic Compound, Against the Progression of Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats
- Foil Acceleration by Intense Pulsed Ion Beam Ablation Plasma
- Pulsed Power Technology and Its Applications at Extreme Energy-Density Research Institute (EDI), Nagaoka
- Characteristics of Intense Pulsed Ion Beam Ablation Plasma and Its Applications to Materials Science
- Cysteinyl Leukotrienes Enhance the Degranulation of Bone Marrow-Derived Mast Cells through the Autocrine Mechanism
- Preparation of Neocarzinostatin Apoprotein Mutants and the Randomized Library on the Chromophore-Binding Cavity(Miscellaneous)
- 4 Pro-R Hydrogen of NADPH was Abstracted for Enzymatic Hydride Transfer by N-Ethylmaleimide Reductase of Yarrowia lipolytica
- Beta-Blockers Prevent Cardiac Events in Japanese Patients With Myocardial Infarction
- Saikokeishito extract prevents progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats
- Realization of Highly Resistive GaAs/Si Interface and Improvement of RF Performance for High Electron-Mobility Transistors Grown on Si Substrates
- Determination of Serum Concentrations of Glycyrrhizin in Humans by Semi-micro High-Performance Liquid Chromatography after Administration of a Therapeutic Dose
- Determination of leukotriene E_4 in human urine using liquid chromatography-tandem mass spectrometry
- Preparation of a Monoclonal Antibody Specific for 5-Methyl-2'-deoxycytidine and Its Application for the Detection of DNA Methylation Levels in Human Peripheral Blood Cells
- A Sandwich Enzyme-linked Immunosorbent Assay for Δ^3, Δ^2-Enoyl-CoA Isomerase in Rat-Tissue Homogenates
- MOLECULAR CLONING OF THE nemA GENE ENCODING N-ETHYLMALEIMIDE REDUCTASE FROM Escherichia coli
- Control Methods of Genetic Algorithms under Changing Environments
- Pulmonary Sequestration Associated with Asymptomatic Aspergillosis
- Combination Therapy of Exercise and Angiotensin-Converting Enzyme Inhibitor Markedly Improves Insulin Sensitivities in Hypertensive Patients With Insulin Resistance
- Modification of Treatment Strategies Over a Period of 14 Years Has Markedly Reduced Cardiac Events Among Post-Myocardial Infarction Patients
- COMPARATIVE ENDOCRINOLOGY OF THE GENETIC REGULATION SYSTEMS AND THE PHYSIOLOGICAL FUNCTIONS OF ESTROGEN SYNTHETASE (AROMATASE)
- Numerical Simulation for the Performance of a Magnetohydrodynamic Accelerator
- Identification of a Polymyxin Produced by a Symbiotic Microorganism Isolated from the Brown Planthopper, Nilaparavata lugens
- Dietary Isothiocyanates Modify Mitochondrial Functions through Their Electrophilic Reaction
- Screening of Antibiotics That Interact with Organic Anion-Transporting Polypeptides 1B1 and 1B3 Using Fluorescent Probes
- Decreased Blood Levels of Lactic Acid and Urinary Excretion of 3-Methylhistidine after Exercise by Chronic Taurine Treatment in Rats
- OJ-101 Distinctive Electrophysiological Properties of Pulmonary Veins in Patients with Paroxysmal Atrial Fibrillation against Isoproterenol(Arrhythmia, Diagnosis/Pathophysiology/EPS 7 (A) : OJ12)(Oral Presentation (Japanese))
- Heat-resistant Properties in Autoclaving of New Polycarbonate Bottles Containing a Disinfectant of Chlorhexidine Digluconate Solution
- Characterization of Powdered Drugs by UV Absorption Spectrum in the Hospital Pharmacy
- Transport of Estrone 3-sulfate Mediated by Organic Anion Transporter OATP4C1 : Estrone 3-sulfate binds to the Different Recognition Site for Digoxin in OATP4C1
- Production of Radicals and Acute Apoptotic Changes of Palisade Cells in Early Steps of Saintpaulia Leaf Spot Appearance
- Acute Morphological Changes of Palisade Cells of Saintpaulia Leaves Induced by a Rapid Temperature Drop
- Simple quantification of lansoprazole and rabeprazole concentrations in human serum by liquid chromatography/tandem mass spectrometry
- Teprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats
- Pulsed Power Technology and Its Applications at Extreme Energy-Density Research Institute (EDI), Nagaoka
- Severe catabolic state after prolonged fasting in cirrhotic patients: effect of oral branched-chain amino-acid-enriched nutrient mixture
- Enhanced Flyer Acceleration by Varying the Ion Beam-Plasma Interaction Field (Special Issue : Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials)
- Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.
- Vitamin E Depletion Enhances Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress
- Expression of Synthetic Human Lysozyme Gene in Escherichia coli