Antinociceptive Effects of St. John's Wort, Harpagophytum Procumbens Extract and Grape Seed Proanthocyanidins Extract in Mice(Pharmacology)

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概要

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• Hypericum perforatum extract (St. John's wort, SJW), Harpagophytum procumbens extract (HPE) and Grape seed proanthocyanidin extract (GSPE) have a broad spectrum of biological activities including antidepressant, anti-inflammatory or anti-oxidant effects. The aim of this study was to clarify antinociceptive properties of SJW, HPE and GSPE in mice with mechanisms that might potentially underlie these activities. Also, the effects of these herbal extracts on the antinociception and plasma and brain concentrations of morphine were examined. Oral pretreatment with SJW (100-1000 mg/kg) and HPE (30-300 mg/kg) attenuated significantly times of licking/biting both first and second phases of formalin injection in mice in the dose-dependent manner, and GSPE (10-300 mg/kg) suppressed second phase. Naloxone (5 mg/kg, s.c.) significantly attenuated antinociceptive effect of HPE but not SJW and GSPE. Formalin injection resulted in significant increase in the content of nitrites/nitrates (NO_x) in mouse spinal cord. The rise of spinal NO_x content by formalin was significantly attenuated by HPE and SJW. The pretreatment with SJW significantly potentiated an antinociceptive effect of morphine (0.3 mg/kg, s.c.), although concentrations of morphine in plasma and brain were not significantly changed by these herbal extracts. In conclusion, the present study has shown that SJW, HPE and GSPE exert significant antinociceptive effects in the formalin test of mice. In addition, opioidergic system seems to be involved in the antinociceptive effect of HPE but not SJW and GSPE. Furthermore, SJW potentiates morphine-induced antinociception possibly by pharmacodynamic interaction.

• 社団法人日本薬学会の論文
• 2008-02-01

著者

• 山田 幸子

  日本大学医学部生化学分野

• 山田 愼一

  トーアエイヨー株式会社

• Umegaki Keizo

  武庫川女子大学 薬学部薬理学

• Umegaki Keizo

  National Institute Of Health And Nutrition

• YAMADA Shizuo

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S

• UCHIDA Shinya

  Department of Pharmacokinetics and Pharmacodynamics and Global COE Program, School of Pharmaceutical

• Uchida S

  Department Of Hospital Pharmacy Hamamatsu University School Of Medicine

• Uchida Shinya

  Department Of Biopharmacy School Of Pharmaceutical Sciences University Of Shizuoka

• Uchida Shinya

  Department Of Hospital Pharmacy Hamamatsu University School Of Medicine

• Yamada S

  Department Of Biopharmacy University Of Shizuoka School Of Pharmaceutical Sciences

• Uchida Shinya

  Department Of Pharmacokinetics And Pharmacodynamics And Global Coe Program School Of Pharmaceutical

• HIRAI Keita

  Department of Pharmacokinetics and Pharmacodynamics and Global COE Program, School of Pharmaceutical

• HATANAKA Junya

  Yokohama Oils and Fats Industry Corporation

• HANATO Junko

  Department of Pharmacokinetics and Pharmacodynamics and Global COE Program, School of Pharmaceutical

• Yamada Shizuo

  Department Of Pharmacokinetics And Pharmacodynamics And Global Coe Program School Of Pharmaceutical

• Yamada Shizuo

  Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka

• Hirai Keita

  Department Of Pharmacokinetics And Pharmacodynamics And Global Coe Program School Of Pharmaceutical

• Umegaki Keizo

  National Inst. Of Health And Nutrition

• Hanato Junko

  School Of Pharmaceutical Sciences University Of Shizuoka

• Hanato Junko

  Department Of Pharmacokinetics And Pharmacodynamics And Global Coe Program School Of Pharmaceutical

• Uchida Shinya

  Department Of Anesthesiology Gunma University Hospital

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