Phospholipid Metabolism in Platelets from Stroke-Prone Spontaneously Hypertensive Rats and Wistar Kyoto Rats
スポンサーリンク
概要
- 論文の詳細を見る
Platelets from stroke-prone spontaneously hypertensive rats (SHRSP) show severe hypofunctions accompanied by defective protein (P47) phosphorylation. To examine the mechanism of platelet hypofunctions, phospholipid metabolism in SHRSP was compared with that in Wistar Kyoto rats (WKY). Phosphatidylinositol (PI) content was 20% less in SHRSP than in WKY, but no changes were observed in other phospholipids. Incorporation of [^3H]-arachidonic acid (AA) into PI and phosphatidylethanolamine (PE) was 12% and 11% lower, and that into phosphatidylcholine (PC) was 6% higher in SHRSP than in WKY. Thrombin-induced diacylglycerol and phosphatidic acid formation were similar in both groups of platelets. Thrombin-induced release of [^<14>C]-AA from the labeled platelets and its metabolism to eicosanoids occurred at similar rates. These results suggest that reduced formation of diacylglycerol, an activator of protein kinase C (PKC), does not cause defective phosphorylation of P47,a substrate of PKC, in SHRSP. However it remains unclear how the lower PI content and the altered distribution of AA in PC and PE is related to SHRSP platelet hypofunctions.
- 公益社団法人日本薬学会の論文
著者
-
Ikeda Masashi
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
-
TOMITA Isao
School of Pharmaceutical Sciences, University of Shizuoka
-
Umegaki Keizo
The National Institute Of Health And Nutrition
-
Umegaki Keizo
National Institute Of Health And Nutrition
-
Umegaki Keizo
静岡県立大学 生活健康科研究
-
Ikeda Masashi
Inst. Of International Education And Res. Dokkyo Medical Univ. School Of Medicine Jpn
-
Ikeda M
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
-
Tomita Isao
Graduate School Of Health Sciences University Of Shizuoka
-
Tomita Isao
School Of Pharmaceutical Sciences University Of Shizuoka
-
Tomita I
Graduate School Of Health Sciences University Of Shizuoka
-
Onda Takeshi
School Of Pharmaceutical Sciences University Of Shizuoka
-
Umegaki K
National Institute Of Health And Nutrition
-
Umegaki Keizo
The National Institute Of Health And Nutrition Shinjuku-ku
-
Ikeda M
Graduate School Of Health Sciences University Of Shizuoka
-
UMEGAKI Keizo
IAA National Institute of Health and Nutrition
-
IKEDA Masahiko
Graduate School of Health Sciences, University of Shizuoka
-
TOMITA Takako
Graduate School of Health Sciences, University of Shizuoka
-
MITSUBORI Tomohiro
School of Pharmaceutical Sciences, University of Shizuoka
-
Tomita T
Graduate School Of Health Sciences University Of Shizuoka
-
Tomita Takako
Graduate School Of Health Sciences University Of Shizuoka
-
Tomita T
University Of Shizuoka Graduate School Of Health Sciences
-
Umegaki Keizo
National Inst. Of Health And Nutrition
-
Ikeda Masahiko
University Of Shizuoka Graduate School Of Health Sciences
-
Mitsubori Tomohiro
School Of Pharmaceutical Sciences University Of Shizuoka
-
Ikeda Masahiko
Graduate School of Health Sci., Univ. of Shizuoka
-
Tomita Takako
Graduate School of Health Sci., Univ. of Shizuoka
関連論文
- Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells
- OJ-105 Diversity of Molecular Forms of BNP in Heart Failure : Difference of Molecular Form of BNP in Atrial and Ventricular Overload(OJ18,Heart Failure (Laboratory/Biomarkers) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japa
- Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- Antinociceptive Effects of St. John's Wort, Harpagophytum Procumbens Extract and Grape Seed Proanthocyanidins Extract in Mice(Pharmacology)
- S-Methyl Methanethiosulfonate, Bio-antimutagen in Homogenates of Cruciferae and Liliaceae Vegetables
- STUDIES ON EYE IRRITATION CAUSED BY CHEMICALS IN RABBITS : III. AN IN VITRO TESTING METHOD USING RAT RED BLOOD CELLS FOR THE PREDICTION OF EYE IRRITATION POTENTIAL OF CHEMICALS
- STUDIES ON EYE IRRITATION CAUSED BY CHEMICALS IN RABBITS : II. STRUCTURE-ACTIVITY RELATIONSHIPS AND IN VITRO APPROACH TO PRIMARY EYE IRRITATION OF SALICYLATES IN RABBITS
- STUDIES ON EYE IRRITATION CAUSED BY CHEMICALS IN RABBITS : 1. A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS APPROACH TO PRIMARY EYE IRRITATION OF CHEMICALS IN RABBITS
- Antioxidative and Hypolipidemic Effects of Dietary Green Tea Polyphenols in ddY Mice Fed Fish Oil-rich Diet
- Polyphenols and Other Components in the Fractions Prepared from the Infusions of Various Tea Leaves
- Antimicrobial Activity of Tea Extracts on Cariogenic Bacterium (Streptococcus mutans)
- Distribution and Fate of LAS Complexes and Quaternary Ammonium Surfactant in the Aquatic Environment (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Form of Linear Alkylbenzenesulfonates in River Water and Formation of Their Complex (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- PACAPの側脳室内投与がプロラクチン分泌に与える影響--成熟雄ラットおよび泌乳ラットを用いた検討
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Role of Fat Tissue Mass on Metabolism and Excretion of Lipophilic Chemicals (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Damaging Effect of Organochlorine Chemicals to Hepatic DNA of Mice
- Effect of Nutrients on Accumulation of Trichloroethylene in Rats (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Effect of Nutrients on Metabolism and Accumulation of Chlorobenzenes in Rats (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Effects of Fat Content in Tissues on Metabolism and Accumulation of Pentachlorobenzene in Rats. (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Anticoagulant and fibrinolytic effects of functional food materials produced by Bacillus subtilis natto
- A Newly Derived Protein From Bacillus subtilis natto With Both Antithrombotic and Fibrinolytic Effects
- Further Investigation Into the Mechanism of Tachykinin NK_2 Receptor-Triggered Serotonin Release From Guinea-Pig Proximal Colon
- Loperamide Inhibits Tachykinin NK_3-Receptor-Triggered Serotonin Release Without Affecting NK_2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa
- Loperamide Inhibits Tachykinin NK3-Receptor-Triggered Serotonin Release Without Affecting NK2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa
- Modification of 5 -Hydroxytryptophan-Evoked 5 -Hydroxytryptamine Formation of Guinea Pig Colonic Mucosa by Reactive Oxygen Species
- Investigation Into the 5-Hydroxytryptophan-Evoked Luminal 5-Hydroxytryptamine Release From the Guinea Pig Colon
- Time-Dependent Induction of Hepatic Cytochrome P450 Enzyme Activity and mRNA Expression by Bilobalide in Rats
- Protective Effects of Quercetin and Its Metabolites on H_2O_2-Induced Chromosomal Damage to WIL2-NS Cells
- Analytical Method of Measuring Tea Catechins in Human Plasma by Solid-Phase Extraction and HPLC with Electrochemical Detection
- Grape Seed Extract Prevents H_2O_2-Induced Chromosomal Damage in Human Lymphoblastoid Cells(Pharmacology)
- Active Oxygens Generation by Flavonoids
- Disturbance of Circadian Rhythm in Heart Rate, Blood Pressure and Locomotive Activity at the Stroke-Onset in Malignant Stroke-Prone Spontaneously Hypertensive Rats
- Phospholipid Metabolism in Platelets from Stroke-Prone Spontaneously Hypertensive Rats and Wistar Kyoto Rats
- Impairment of Endothelium-Dependent Relaxation by Diesel Exhaust Particles in Rat Thoracic Aorta
- Effects of Theanine on Alcohol Metabolism and Hepatic Toxicity(Biopharmacy)
- EFFECTS OF MEPANIPYRIM ON LIPID METABOLISM IN RATS
- MEPANIPYRIM INDUCES FATTY LIVER IN RATS BUT NOT IN MICE AND DOGS
- Distribution and Mobilization of Chlorinated Benzenes in Fat Cells from Rats Given Various Chlorinated Benzenes : Comparison between Young and Adult Rats (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Physical Exercise Induces Oxidation of Plasma Protein Thiols to Cysteine Mixed Disulfides in Humans
- Altered structure and expression of Trk C gene on SHR and hypertensive substrains
- Expression Mechanism of Nerve Growth Factor Gene in Spontaneously Hypertensive Rats
- Use of Dietary Supplements among Preschool Children in Japan
- Differences in the Influence of AIN-Purified and Non-purified Diets on the Development of Hypertension in SHR and DOCA-salt Hypertensive Rats
- Sustained Contraction to Angiotensin II and Impaired Calcium-Pump Activity in Smooth Muscle from SHRSP
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-Term Consumption of a Large Amount of Tea Catechins on Chromosomal Damage, Oxidative Stress Markers, Serum Lipid, Folic Acid, and Total Homocysteine Levels : A Randomized, Double-Blind, Controlled Study
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- Nucleotide Sequence Analysis of Protein Kinase Ca and Low Affinity Nerve Growth Factor Receptor Genes in SHRSP
- Brain Microtubule Assembly Following Carotid Artery Occlusion-Reperfusion in Spontaneously Hypertensive Rat
- Inhibitory effects of milk minerals on salt-induced high blood pressure and elevation of lipid peroxides levels in SHR
- Enhanced Contractile Responses without Impairment of Endotheliumdependent Relaxation in Isolated Mesenteric Vascular Bed Preparation from SHRSP
- Enhancement of Endothelium-Dependent Relaxation (EDR) in the Aorta from SHRSP at Developmental Ages of Hypertension, and Effects of Hypotensive Treatment on EDR in SHRSP
- Correlation Analysis of Hypertension and Vascular Reactivity in Isolated Mesenteric Vascular Bed (MVB) Preparations in WKY, SHRSP, F1 and Backcross genrations
- Reduced spontaneous relaxation following maximum contraction by Angiotensin II in endothelium-denuded aorta from SHRSP
- Arachidonic acid (AA) metabolism in platelets from SHRSP and WKY
- Ca2+ dependency of protein kinase C activity in SHRSP and WKY platelets
- Ca2+-dependency of protein kinase C purified from SHRSP and WKY platelets
- Correlation Analysis of Blood Pressure and Platelet Aggregation in SHRSP, WKY, F1 and Backcross generations
- Sensitivity of platelet functions to cytosolic free calcium in SHRSP and WKY
- Thrombin-induced changes in intracellular Ca2+-concentration and aggregation in platelets from SHRSP and WKY
- A morphological study of SHRSP and WKY platelets in relation to their physiological functions
- Effects of Restricted Feeding on the Absorption, Metabolism, and Accumulation of Pentachlorobenzene in Rats.
- Improved Method for the Analysis of Ascorbic Acid in Plasma by High-Performance Liquid Chromatography with Electrochemical Detection.
- A Transient Rise in Serum NOx Concentration at the Time of Stroke in Malignant Stroke-Prone Spontaneously Hypertensive Rats
- Feeding of Palm Oil Carotene to Mice Did not Modify X-Ray-Induced Chromosomal Damage in Bone Marrow Cells.
- Sustained contraction by Angiotensin II in smooth muscle of thoracic aorta from SHRSP and the alteredintracellular Ca2+-homeostasis in SHRSP
- Effects of Cholesterol-diet on the Incidence of Stroke and Life-span in Malignant Stroke Prone Spontaneously hypertensive rats
- Attenuated Spontaneous Relaxation following the Maximal Contraction in Endothelium-denuded Mesenteric Vascular Bed Preparations from SHRSP