Further Investigation Into the Mechanism of Tachykinin NK_2 Receptor-Triggered Serotonin Release From Guinea-Pig Proximal Colon
スポンサーリンク
概要
- 論文の詳細を見る
The effects of the monoamine oxidase A (MAO-A) inhibitor clorgyline, the L-type calcium-channel blocker nicardipine, the syntaxin inhibitor botulinum toxin type C, and the potent thiol-oxidant phenylarsine oxide (PAO) on the selective tachykinin NK2–receptor agonist [β-Ala8]-neurokinin A4-10 [βAla-NKA-(4-10)]–evoked 5-hydroxytryptamine (5-HT) outflow from colonic enterochromaffin (EC) cells was investigated in vitro using isolated guinea-pig proximal colon. The βAla-NKA-(4-10)–evoked outflow of 5-HT from clorgyline-treated colonic strips was markedly higher than that from clorgyline-untreated colonic strips. The βAla-NKA-(4-10)–evoked 5-HT outflow from the clorgyline-treated colonic strips was sensitive to nicardipine or botulinum toxin type C. Moreover, PAO concentration-dependently suppressed the βAla-NKA-(4-10)–evoked 5-HT outflow from the clorgyline-treated colonic strips. The suppressant action of PAO was reversed by the reducing agent dithiothrietol, but was not blocked by the protein tyrosine kinase inhibitor genistein. These results suggest that the tachykinin NK2 receptor–triggered 5-HT release from guinea-pig colonic EC cells is mediated by syntaxin-related exocytosis mechanisms and that colonic mucosa MAO-A activity has the important function of modulating the tachykinin NK2 receptor–triggered 5-HT release. It also appears that PAO-mediated sulfhydryl oxidation plays a role in modulating the tachykinin NK2 receptor–triggered 5-HT release through a mechanism independent of inhibition of protein tyrosine phosphatase activity.
- 社団法人 日本薬理学会の論文
- 2009-05-20
著者
-
Ikeda Masashi
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
-
Ikeda Masashi
Inst. Of International Education And Res. Dokkyo Medical Univ. School Of Medicine Jpn
-
Ikeda M
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
-
Ikeda Masashi
Institu Of International Education And Research Dokkyo Medical University
-
Kamikawa Yuichiro
Department of Pharmacology, Dokkyo University School of Medicine
-
KOJIMA Shu-ichi
Department of Pharmacology, Dokkyo Medical University School of Medicine
-
Ikeda M
Graduate School Of Health Sciences University Of Shizuoka
-
Kojima S
Department Of Pharmacology Dokkyo Medical University School Of Medicine
-
Kojima Shu-ichi
Department Of Engineering Science Kyoto University
-
Kamikawa Y
Department Of Pharmacology Dokkyo Medical University School Of Medicine
-
Kamikawa Yuichiro
Department Of Pharmacology Dokkyo Medical University School Of Medicine
-
Kamikawa Yuichiro
Department of Pharmacology, Dokkyo Medical University School of Medicine
関連論文
- OJ-105 Diversity of Molecular Forms of BNP in Heart Failure : Difference of Molecular Form of BNP in Atrial and Ventricular Overload(OJ18,Heart Failure (Laboratory/Biomarkers) (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japa
- PACAPの側脳室内投与がプロラクチン分泌に与える影響--成熟雄ラットおよび泌乳ラットを用いた検討
- Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids
- Anticoagulant and fibrinolytic effects of functional food materials produced by Bacillus subtilis natto
- A Newly Derived Protein From Bacillus subtilis natto With Both Antithrombotic and Fibrinolytic Effects
- Further Investigation Into the Mechanism of Tachykinin NK_2 Receptor-Triggered Serotonin Release From Guinea-Pig Proximal Colon
- Loperamide Inhibits Tachykinin NK_3-Receptor-Triggered Serotonin Release Without Affecting NK_2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa
- Loperamide Inhibits Tachykinin NK3-Receptor-Triggered Serotonin Release Without Affecting NK2-Receptor-Triggered Serotonin Release From Guinea Pig Colonic Mucosa
- Modification of 5 -Hydroxytryptophan-Evoked 5 -Hydroxytryptamine Formation of Guinea Pig Colonic Mucosa by Reactive Oxygen Species
- Investigation Into the 5-Hydroxytryptophan-Evoked Luminal 5-Hydroxytryptamine Release From the Guinea Pig Colon
- Muscularis mucosae : the forgotten sibling
- Disturbance of Circadian Rhythm in Heart Rate, Blood Pressure and Locomotive Activity at the Stroke-Onset in Malignant Stroke-Prone Spontaneously Hypertensive Rats
- Phospholipid Metabolism in Platelets from Stroke-Prone Spontaneously Hypertensive Rats and Wistar Kyoto Rats
- Impairment of Endothelium-Dependent Relaxation by Diesel Exhaust Particles in Rat Thoracic Aorta
- Preservative solution for freeze-storage of surgically excised human colon to enable study of smooth muscle function in vitro
- Effects of Cyclophosphamide on the Kaolin Consumption (Pica Behavior) in Five Strain Adult Male Rats
- Angular Dependence of Sputtering Yield of Au on Bombardment by 15 to 60 keV Ar^+
- Calcitonin Gene : Related Peptide Inhibits Nonadrenergic Noncholinergic Contraction of Guinea Pig Distal Colon
- AUGMENTATION OF THE VAGALLY-MEDIATED RESPONSE TO 5-HYDROXYTRYPTAMINE IN THE ANAPHYLACTICALLY-DESENSITIZED ATRIA OF GUINEA-PIGS "IN VITRO"
- In vitro Comparison of the Intrinsic Activity of Functional Antagonism between β-agonists and Spasmogens in the Guinea-pig Tracheal Muscle
- Assessments of Student Fitness to Practice among Nursing Students