Disturbance of Circadian Rhythm in Heart Rate, Blood Pressure and Locomotive Activity at the Stroke-Onset in Malignant Stroke-Prone Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP), separated from SHRSP, develop severe hypertension and spontaneously develop stroke at early ages. Using this model of cerebrovascular stroke, influence of stroke-onset on the autonomic nervous system was investigated. Heart rate (HR), systolic and diastolic blood pressures (SBP and DBP) and locomotive activity were monitored during development of stroke using a telemetry system. Stroke-onset was assessed by neurologic symptoms, changes in body weight, fluid intake and serum NOx level. The rat displayed a nocturnal pattern of circadian rhythms. At stroke-onset, mean HR over 24 h increased by 20 to 30 bpm and rapidly increased at post stroke, approximately 100 bpm higher than that at pre stroke. Circadian variation in HR, which was normally 50 bpm higher during night than during day, attenuated at stroke-onset, and it was blunted or reversed at post stroke. BP variation, which was approximately 7 mmHg higher at night than at day, decreased one or two days before stroke-onset and reversed at post stroke, especially in DBP. Insufficient falls in HR and BP during the day mainly accounted for the disturbed circadian variations. Variation of locomotive activity also decreased. These changes serve as reliable and accurate markers for stroke-onset in evaluation of drugs for the prevention and outcome predictions of stroke.
- 社団法人 日本薬理学会の論文
- 2001-02-01
著者
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Ikeda Masashi
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
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UMEGAKI KEIZO
Division of Applied Food Research, National Institute of Health and Nutrition
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Umegaki Keizo
The National Institute Of Health And Nutrition
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Umegaki Keizo
静岡県立大学 生活健康科研究
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Ikeda Masashi
Inst. Of International Education And Res. Dokkyo Medical Univ. School Of Medicine Jpn
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Ikeda M
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
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Tomita Isao
Graduate School Of Health Sciences University Of Shizuoka
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Sagai Masaru
Division Of Nursing And Human Sciences Faculty Of Health Sciences Aomori University Of Health And We
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Tabuchi Masaki
Graduate School Of Health Sciences University Of Shizuoka
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Suzuki Motohisa
Graduate School Of Health Sciences University Of Shizuoka
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ITO Tomohiro
Graduate School of Engineering, Yamagata University
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Tomita I
Graduate School Of Health Sciences University Of Shizuoka
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Umegaki K
National Institute Of Health And Nutrition
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Umegaki Keizo
The National Institute Of Health And Nutrition Shinjuku-ku
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Ikeda M
Graduate School Of Health Sciences University Of Shizuoka
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UMEGAKI Keizo
IAA National Institute of Health and Nutrition
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IKEDA Masahiko
Graduate School of Health Sciences, University of Shizuoka
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TOMITA Takako
Graduate School of Health Sciences, University of Shizuoka
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Tomita T
Graduate School Of Health Sciences University Of Shizuoka
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Tomita Takako
Graduate School Of Health Sciences University Of Shizuoka
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Tomita T
University Of Shizuoka Graduate School Of Health Sciences
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Ito Tomohiro
Graduate School Of Engineering Yamagata University
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Ikeda Masahiko
University Of Shizuoka Graduate School Of Health Sciences
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Umegaki Keizo
Division Of Applied Food Research National Institute Of Health And Nutrition
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Ikeda Masahiko
Graduate School of Health Sci., Univ. of Shizuoka
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Tomita Takako
Graduate School of Health Sci., Univ. of Shizuoka
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