MEPANIPYRIM INDUCES FATTY LIVER IN RATS BUT NOT IN MICE AND DOGS
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概要
- 論文の詳細を見る
Mepanipyrim, a new fungicide, was administered orally to rats, mice and dogs for 13 weeks to clarify its toxic profiles. Hepatotoxicities were observed characteristically in these species with high concentrations of mepanipyrim; more than 200 ppm in rats, more than 1,000 ppm in mice, and more than 50 mg/kg/day in dogs. In rats, obvious fatty vacuolation in the perilobular hepatocytes and changes in the serum-lipid concentrations such as total cholesterol(TC), triglyceride(TG), phospholipid(PL)and non-esterified fatty acid(NEFA)were observed. This fatty liver appeared to be based on the alteration of lipid metabolism. In contrast, no remarkable changes were observed in mice and dogs except for an enhancement of anisonucleosis in mice or a lipofuscin deposition in Kuppffer cells and hepatocytes in dogs. It appeared that there species differences in the hepatotoxicities of mepanipyrim.
- 日本トキシコロジー学会の論文
- 1998-08-17
著者
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Murata Kyoji
Life Science Research Institute Kumiai Chemical Co. Ltd.
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INOUE Hiroyuki
Biosafety Research Center, Foods, Drugs and Pesticides
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TOMITA Takako
Graduate School of Health Sciences, University of Shizuoka
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Tomita Takako
Graduate School Of Health Sciences University Of Shizuoka
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TERADA Megumi
Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.
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MIZUHASHI Fukutaro
Life Science Research Institute, Kumiai Chemical Industry Co., Ltd.
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Terada Megumi
Life Science Research Institute Kumiai Chemical Industry Co. Ltd.
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Mizuhashi Fukutaro
Life Science Research Institute Kumiai Chemical Industry Co. Ltd.
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Inoue Hiroyuki
Biosafety Research Center Foods Drugs And Pesticides
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Inoue Hiroyuki
Biosafety Research Center Food Drugs And Pesticides
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Tomita Takako
Graduate School of Health Sci., Univ. of Shizuoka
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