CARCINOGENICITY TEST OF POLYOXYETHYLENE(10)NONYLPHENYL ETHER (NP-10) IN FEMALE B6C3F_1 MICE
スポンサーリンク
概要
- 論文の詳細を見る
A carcinogenicity study of polyoxyethylene(10)nonylphenyl ether (NP-10) to B6C3F_1 mouse was performed using 50 females per group of 4 study groups, or 200 mice in total. Diets containing NP-10 at 0, 500, 1500 and 4500 ppm were prepared and orally administered to the animals repeatedly for 104 weeks, and observation of general conditions, body weight analysis, food consumption analysis, hematologic examination, organ weight analysis and pathological examination were performed. The results are summarized as follows. The mean intake of the test substance in the 500, 1500 and 4500 ppm groups for 104 weeks was 81.5, 254 and 873 mg/kg/day, respectively. There were no differences observed in mortality among the groups and the mortality did not exceed the background data in any groups. There were no signs attributable to the administration of the test substance, and various signs which increased in occurrence with aging were observed in all groups at a similar frequency. Body weight gain was suppressed only in the 4500 ppm group throughout the entire administration period. Food consumption was increased in all treated groups around the early stage of administration and, thereafter, in the 1500 and 4500 ppm groups until the mid-stage of administration. Decreased food efficiency was observed in the 4500 ppm group alone. As a result of the hematologic examination, no changes attributable to the administration of the test substance were observed in any groups. As a result of the organ weight analysis, lower absolute weights of the liver and kidney and higher relative weights of the brain, liver and kidney, which were considered to be changes accompanying the suppressed body weight gain, were observed in the 4500 ppm group. The pathological examination revealed no marked changes in the gross findings in the treated groups. As a result of the histological examination, there were no neoplastic or non-neoplastic lesions in the treated groups which were unequivocally observed to have increased in occurrence. As the above findings show, NP-10 did not cause any increase in the incidence of neoplastic lesions in the mouse by oral administration for 2 years at 873 mg/kg/day (4500 ppm) and was determined to have no carcinogenicity..
- 日本トキシコロジー学会の論文
- 1999-12-20
著者
-
Yamamoto Toshio
食品農医薬品安全性評価センター
-
Yamamoto Toshio
Biosafety Research Center Foods Drugs And Pesticides
-
Enomoto Makoto
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
-
Enomoto M
Biosafety Res. Center Foods Drugs And Pesticides Shizuoka Jpn
-
YAMAMOTO Toshinobu
Drug Development Laboratories, Safety Evaluation, Yoshitomi Pharmaceutical Industries, Ltd.
-
MORITA Kyoji
Department of Pharmacology, Tokushima University School of Medicine
-
INOUE Hiroyuki
Biosafety Research Center, Foods, Drugs and Pesticides
-
SHOJI Akinori
Biosafety Research Center, Foods, Drugs and Pesticides
-
WATARI Nobuaki
Biosafety Research Center, Foods, Drugs and Pesticides
-
HIROUCHI Yasuhiko
Biosafety Research Center, Foods, Drugs and Pesticides
-
Shoji Akinori
Biosafety Research Center Foods Drugs And Pesticides
-
Watari Nobuaki
Biosafety Research Center Foods Drugs And Pesticides
-
Yamamoto T
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
-
Morita K
Department Of Pharmacology Tokushima University School Of Medicine
-
Enomoto Makoto
Biosafety Research Center Foods Drugs And Pesticides
-
Hirouchi Yasuhiko
Biosafety Research Center Foods Drugs And Pesticides
-
Yamamoto T
Inst. Soc. Techno‐innovation Agriculture Forestry And Fisheries (staff) Ibaraki Jpn
-
Inoue H
Biosafety Research Center Foods Drugs And Pesticides
-
Enomoto Makoto
Biosafety Research Center
-
Inoue Hiroyuki
Biosafety Research Center Foods Drugs And Pesticides
-
Yamamoto Toshio
Biosafety Research Center Foods Drug And Pesticides
-
Inoue Hiroyuki
Biosafety Research Center Food Drugs And Pesticides
関連論文
- Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes
- Regulation of the blood-biliary barrier : interaction between gap and tight junctions in hepatocytes
- FLOW CYTOMETRIC DETECTION AND ANALYSIS OF TAILLESS SPERM CAUSED BY SONICATION OR A CHEMICAL AGENT
- 22A-09-3 Flow cytometric analysis (FCM) of sperms taken from rats treated with nitrobenzene (NB).
- EVALUATION OF RAT SPERM BY FLOW CYTOMETRY : SIMULTANEOUS ANALYSIS OF SPERM COUNT AND SPERM VIABILITY
- Scattering Observables of NN Interaction in the SU_6 Quark Model
- ELEVATION OF STEROID 5α-REDUCTASE mRNA LEVELS IN RAT CEREBELLUM BY TOLUENE INHALATION : POSSIBLE RELATION TO GFAP EXPRESSION
- Cytotoxic Effect of Paraquat on Rat C6 Glioma Cells : Evidence for the Possibility of Non-oxidative Damage to the Cells
- Relevance of Heat-Shock Protein 70 Expression as Histological Marker of Paraquat-Induced Damage to Rat Liver Cells
- Immunohistochemical Studies on Paraquat-Induced Damage to Neuronal and Glial Cells in Rat Hippocampus
- ORAL CHRONIC TOXICITY AND CARCINOGENICITY TEST OF POLYOXYETHYLENE(10)NONYLPHENYL ETHER (NP-10) IN FEMALE F344 RATS
- CARCINOGENICITY TEST OF POLYOXYETHYLENE(10)NONYLPHENYL ETHER (NP-10) IN FEMALE B6C3F_1 MICE
- ANALYSIS OF BACKGROUND PATHOLOGICAL LESIONS SEEN IN LONG-TERM TOXICITY TESTS (1). THE COMBINED HISTOPATHOLOGICAL CHANGES OBSERVED IN RATS OR MICE
- (+)-[^3H] Isradipine and [^3H] Glyburide Bindings to Heart and Lung Membranes From Rats With Monocrotaline-Induced Pulmonary Hypertension
- Analysis of Ras Gene Mutations in Main Spontaneously-occurring Non-epithelial Tumors of B6C3F_1 Mouse
- Two Cases of Rare Hepatocellular Nodular Lesion Caused by Circulatory Disturbance in Rat Livers
- A Case of Pancreatic Nesidioblastosis with Aberrant Islet Cell Proliferation in a Beagle
- Involvement of Adenosine A_2 Receptors in the Changes of Tissue Factor-Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes in Endothelial Cells
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- P12-08 Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-metabolizing Enzymes In Vivo and In Vitro
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Changes of Tissue Factor-Dependent Coagulant Activity Mediated by Adhesion Between Polymorphonuclear Leukocytes and Endothelial Cells
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- ACUTE TOXICITY OF PIERISIN-1, A CYTOTOXIC PROTEIN FROM PIERIS RAPAE, IN MOUSE AND RAT
- MUTAGENICITY TESTING OF ST-FILM WITH THE AMES TEST, CHROMOSOME TEST IN VITRO AND MICRONUCLEUS TEST IN FEMALE MICE
- B-33 Utilization of the flow cytometry hematological examination in the toxicity studies
- Expression and regulation of hepatic gap junctions by interleukin-1β (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- The effect of fasting time in mice on the blood-chemistry and histopathological changes in the stomach. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- QUESTIONING THE USEFULNESS OF THE NON-PARAMETRIC ANALYSIS OF QUANTITATIVE DATA BY TRANSFORMATION INTO RANKED DATA IN TOXICITY STUDIES
- MEPANIPYRIM INDUCES FATTY LIVER IN RATS BUT NOT IN MICE AND DOGS
- In vitro 8-hydroxydeoxyguanosine measurement by ELISA method as a marker of DNA bases injuries by hydrogen peroxide or ultraviolet.(GENERAL SESSION BY POSTER PRESENTATION)(CARCINOGENICITY)
- A-15 IN VITRO TERATOGENICITY TESTING USING THE RAT EMBRYO CULTURE SYSTEM : (3) EFFECTS OF CYCLOPHOSPHAMIDE ON RAT EMBRYONIC DEVELOPMENT IN VITRO AND IN VIVO
- 2C-02 Study on urinalysis and bloodchemistry as an index of renaltoxicity.
- "P-75 Changes of Erythrocyte and Serum Erythropoietin in Beagle dog after Hemmorhagic Anemia.
- Studies on the Application of the Historical Control Data Obtained from the Blood Chemistry of Toxicity Studies with Dogs.
- P12-05 A Basic Evaluation on the ADVIA120 hematology system for multi-species.
- STATISTICAL ANALYTICAL METHODS FOR COMPARING THE INCIDENCE OF TUMORS TO THE HISTORICAL CONTROL DATA
- Analysis of organ weight data in Beagle dog
- "C-3 Effect of the sperm of rats treated with Methacrylic Acid, 2,3-Epoxypropyl Ester.
- Biosynthesis, Storage and Release of Catecholamine and the Effects of Drugs on these Processes
- B-34 Age-associated historical data of the hematology and blood biochemistry in F344 rats and B6C3F_1 mice
- OARATHYROID MORPHOLOGY IN RATS AFTER ACTIVE VITAMIN D_3 ADMINISTRATION
- GROSS AND MICROSCOPIC CHARACTERISTICS OF LIVER LESIONS INDUCED BY DIRECT INJECTION OF PENTOBARBITAL SODIUM INTO RATS
- 21WA-01-2 Measurement of hormone concentration in rat serum by automated immunoassay systems.
- A SEARCH FOR CHEMICAL AGENTS CAUSING HUMAN CANCER : LESSONS LEARNED FROM RODENT CARCINOGENICITY STUDIES
- Application of High Performance Liquid Chromatography to Bloodstain Examinations
- The effect of phenobarbital and 3-methyl-cholathrene on thyroid hormone and UDP-GT activity in rats.(GENERAL SESSION BY ORAL PRESENTATION)(ENDOCRINE SYSTEM)
- Cartilage-forming Tumors at Multiple Sites in Two B6C3F_1 Mice
- Effects of Flavonoid Compounds on the Activity of NADPH Diaphorase Prepared from the Mouse Brain.
- Analysis of Ras Gene Mutations in Main Spontaneously-occurring Non-epithelial Tumors of B6C3F1 Mouse.