Cytotoxic Effect of Paraquat on Rat C6 Glioma Cells : Evidence for the Possibility of Non-oxidative Damage to the Cells
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概要
- 論文の詳細を見る
Although paraquat has been shown to cause oxidative damage to neuronal cells, little is known about its effect on glial cells. Thus the effect of paraquat on glial cells was examined using rat C6 glioma cells as a model system. Paraquat reduced cell viability in a concentration- and time-dependent manner, and this toxic effect was not significantly attenuated by various kinds of antioxidants. Furthermore, paraquat failed to increase 8-hydroxy-deoxyguanosine formation in the cells. These results indicate that paraquat can be toxic to glial cells and suggest that this cytotoxic effect may not be associated with the oxidative damage to the cells.
- 社団法人 日本薬理学会の論文
著者
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KUBO Shin-ichi
Department of Legal Medicine, School of Medicine, The University of Tokushima
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Kubo Shin-ichi
Department Of Forensic Medicine Institute Of Health Biosciences The University Of Tokushima Graduate
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TOKUNAGA Itsuo
Department of Forensic Medicine, Institute of Health Biosciences, The University of Tokushima Gradua
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MORITA Kyoji
Department of Pharmacology, Tokushima University School of Medicine
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Morita K
Department Of Pharmacology Tokushima University School Of Medicine
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Kubo Shuji
Department Of Forensic Medicine Institute Of Health Biosciences The University Of Tokushima Graduate
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Morita Kyoji
Department Of Pharmacology Tokushima University School Of Medicine
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Tokunaga I
Department Of Forensic Medicine Institute Of Health Biosciences The University Of Tokushima Graduate
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Tokunaga Itsuo
Department Of Forensic Medicine The University Of Tokushima Graduate School
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