Alleviative Effects of Quercetin and Onion on Male Reproductive Toxicity Induced by Diesel Exhaust Particles
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概要
- 論文の詳細を見る
Diesel exhaust particles (DEPs) are particulate matter from diesel exhaust that contain many toxic compounds, such as polyaromatic hydrocarbons (PAHs). Some toxicities of PAH are thought to be expressed via aryl hydrocarbon receptors (AhRs). The male reproductive toxicity of DEPs might depend on AhR activation induced by PAHs. We hypothesized that AhR antagonists protect against the male reproductive toxicity of DEPs. Quercetin is a flavonoid and a well-known AhR antagonist, while onion contains many flavonoids, including quercetin. Hence, we examined whether quercetin and onion have alleviative effects against the male reproductive toxicity induced by DEPs. BALB/c male mice were fed quercetin- or onion-containing diets and received 10 injections of DEP suspension or vehicle into the dorsal subcutaneous layer over 5 weeks. The mice were euthanized at 2 weeks, after the last treatment, and their organs were collected. Daily sperm production and total incidence of sperm abnormalities were significantly affected in the DEP groups as compared with the vehicle group, but the total incidence of sperm abnormalities in the quercetin + DEP-treated mice was significantly reduced as compared with the DEP-treated mice. The numbers of Sertoli cells were significantly decreased in DEP-treated mice as compared with the vehicle-treated mice, but, the numbers of Sertoli cells were significantly increased in the quercetin and the onion + DEP-treated mice as compared with the DEP-treated mice. These results clearly indicate alleviative effects of quercetin and onion against the male reproductive toxicity induced by DEP.
- 社団法人 日本農芸化学会の論文
- 2008-05-23
著者
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Watanabe Gen
岐阜大学 連合獣医学研究科基礎獣医学
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Watanabe G
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Taya K
Dep. Of Basic Veterinary Sci. The United Graduate School Of Veterinary Sciences Gifu Univ.
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WATANABE Gen
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Taya Kazuyoshi
中華人民共和国
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Sagai Masaru
Dep. Of Life Sciences Graduate School Of Health Sciences Aomori Univ. Of Health And Welfare
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Sagai Masaru
Division Of Nursing And Human Sciences Faculty Of Health Sciences Aomori University Of Health And We
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.,
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SUGANUMA Hiroyuki
Research Institute, Kagome Co., LTD.
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AIZAWA Koichi
Research Institute, Kagome Co., Ltd.
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Taya Kazuyoshi
東京農工大学 農学部獣医学科獣医生理学
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IZAWA Hiromi
Division of Human Sciences, Faculty of Health Sciences, Aomori University of Health and Welfare
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KOHARA Machiko
Department of Life Sciences, Graduate School of Health Sciences, Aomori University of Health and Wel
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Aizawa Koichi
Research Institute Kagome Co. Ltd.
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Suganuma Hiroyuki
Research Institute Kagome Co. Ltd.
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Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
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Inakuma Takahiro
Research Institute Kagome Co. Ltd
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Kohara Machiko
Department Of Life Sciences Graduate School Of Health Sciences Aomori University Of Health And Welfa
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Sagai Masaru
Division Of Human Sciences Faculty Of Health Sciences Aomori University Of Health And Welfare
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Izawa Hiromi
Division Of Human Sciences Faculty Of Health Sciences Aomori University Of Health And Welfare
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.
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