Direct Effects of Prolactin on Adrenal Steroid Release in Male Hatano High-Avoidance (HAA) Rats May be Mediated Through Janus Kinase 2 (Jak2) Activity
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概要
- 論文の詳細を見る
Prolactin (PRL) has been proposed to directly stimulate corticosterone release. However, the role of PRL on adrenocortical function in male HAA rats has not been fully clarified. The aim of this study was to investigate the effect of PRL on the secretion of corticosterone and progesterone using an in vitro cell culture system in male rats. Administration of PRL (10-7 and 10-6 M) resulted in dose-dependent increases in corticosterone and progesterone release. Cotreatment with PRL produced an increase in the stimulatory effects of ACTH-induced corticosterone and progesterone secretion. However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor. In addition, administration of AG490 blunted the significant inhibition of ACTH-induced corticosterone and progesterone secretion by PRL. These results demonstrated that PRL could act directly on the adrenal gland to drive corticosterone and progesterone secretion in male rats. Additionally, the results emphasize that PRL stimulatation of adrenal steroid release may be mediated through Jak2 activity.
- 日本繁殖生物学会の論文
- 2007-08-01
著者
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Watanabe Gen
Lab. Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of Agricul
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Taya K
Tokyo Univ. Agriculture And Technol. Tokyo
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Taya K
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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WATANABE Gen
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Taya Kazuyoshi
中華人民共和国
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Ohta Ryo
Hatano Res. Inst. Food And Drug Safety Center
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Ohta Ryo
岐阜大学 大学院連合獣医学研究科
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Jaroenporn Sukanya
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu Univ
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NAGAOKA Kentaro
Laboratory of Animal Breeding, Faculty of Agriculture, The University of Tokyo
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Ohta Ryo
Safety Testing Laboratory Research Administration Hatano Research Institute Food And Drug Safety Cen
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Watanabe Gen
中華人民共和国
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Takano Kaoru
Laboratory Of Experimental Animal Models Division Of Bioresources National Institute Of Biomedical I
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Nakamura Katsuhiro
Daiichi Fine Chemical Co. Ltd. Toyama Jpn
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Ohta Ryo
Safety Testing Laboratory Food And Drug Safety Center Hatano Research Institute
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Nagaoka Kentaro
Laboratory Of Animal Breeding Faculty Of Agriculture The University Of Tokyo
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Jaroenporn Sukanya
Primate Research Unit Department Of Biology Faculty Of Science Chulalongkorn University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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NAGAOKA Kentaro
Laboratory of Animal Breeding and Reproduction, University of Tokyo, Tokyo 113-8657, Japan
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Nagaoka Kentaro
Laboratory of Animal Breeding and Reproduction, University of Tokyo
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