A New More Potent Analogue of LH-RH : [Des-Gly-NH<SUB>2</SUB><SUP>10</SUP>, Pro-ethylamide<SUP>9</SUP>]-LH-RH
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概要
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The effect of a new anaiogue [Des-Gly-NH<SUB>2</SUB><SUP>10</SUP>, pro-ethylamide<SUP>9</SUP>]-LH-RH (TAP-031) on the release of LH and FSH was compared with the effect of synthetic LH-RH by both the <I>in vivo</I> and <I>in vitro</I> assay method. The concentration of FSH and LH in serum and medium was determined by NIAMD-rat hormone radioimmunoassay kits. Single intravenous injections of 1, 10, 100 and 1, 000mμg of TAP-031 in ovariectomized-estrogenprogesterone blocked rats (O.E.P.), induced the increases of serum LH 5 to 60min after injection. In contrast, single injections of the same four doses of LH-RH in O.E.P. rats induced the increase of serum LH at 5 to 30min after injection. Intravenous single injections of 1 and 10mμg of TAP-031 and LH-RH induced no significant elevations of serum FSH in O.E.P. rats. However, injections of 100 and 1, 000mμg of TAP-031 and LH-RH induced significant elevations of serum FSH 1 to 2 hrs after injection of TAP-031, and 10 to 60min after the injection of LH-RH, respectively. The appearance of peak in serum LH and FSH was remarkably postponed in administration of over 100mμg of TAP-031. The increase in serum LH and FSH was larger in administration of TAP-031 than in administration of LH-RH.<BR>In <I>in vitro</I> rat pituitary incubation experiments, LH and FSH releasing activities of TAP-031 were shown to be stronger than those of LH-RH.<BR>These data offer the evidences demonstrating that TAP-031 has the stronger and more prolonged LH and FSH releasing activities both <I>in vivo</I> and <I>in vitro</I> than synthetic LH-RH.
- 社団法人 日本内分泌学会の論文
著者
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Igarashi Masao
Department Of Obstetrics And Gynecology School Of Medicine Gunma University
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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IGARASHI MASAO
Department of Obsterics and Gynecology, Gunma University School of Medicine
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