Short-and Auto-Feedback Mechanism of LH

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The effect of implantation of LH (NIH LH Ovine) into the median eminence (ME) area or into the anterior pituitary of ovariectomized rats on pituitary and plasma gonadotropin was investigated. Seven days after implantation, the animals were sacrificed, and FSH and LH activity was determined according to Igarashi-McCann (Igarashi et al., 1964) method and Parlow-McCann-Yokota method (Yokoyama et al., 1965), respectively. LH implantation in ME significantly decreased plasma FSH levels in two out of the three experiments, and pituitary FSH content in one out of the three experiments. On the other hand, plasma LH levels of LH implanted animals showed a significant decrease in two out of the three experiments. Pituitary LH content of LH implanted animals showed no change in all the three experiments. LH implantation in anterior pituitary induced no constant change in plasma and pituitary FSH, a significant decrease in plasma LH levels in one and a tendency of decrease in the other two out of the three experiments, while pituitary LH content did not change. It is concluded that when LH exerts a direct action on the ME, release of FSH and LH is inhibited. On the other hand, when LH exerts a direct action on the anterior pituitary, release of LH only is inhibited.
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