Role of Prostaglandin F<SUB>2α</SUB> in Ovulation
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概要
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Using radioimmunoassay procedures, the levels of plasma, uterine and ovarian prostaglandin (PG) F<SUB>2α</SUB>, and those of plasma estradiol and progesterone were measured in intact, hysterectomized or ovariectomized immature female rats pretreated with PMS and subsequent HCG. Occurrenee of ovulation was confirmed at 8 hours after the HCG administration not only in the intact rats but also in the hysterectomized rats.<BR>The levels of plasma estradiol and progesterone, and of uterine and ovarian PGF <SUB>2α</SUB> rose with the PMS injection alone, but they did not reach the peaks before the HCG administration. Both plasma estradiol and uterine PGF<SUB>2α</SUB> showed a peak at 2 hours after the HCG injection. These peaks were antecedent 2 or 6 hours before the peaks of ovarian and plasma PGF <SUB>2α</SUB>, respectively. However, such increase of uterine PGF <SUB>2α</SUB> does not seem to be indispensable for ovulation, because ovulation could occur in the hysterectomized rats.<BR>The levels of ovarian PGF <SUB>2α</SUB> showed a high plateau from 4 to 8 hours after the HCG injection, and then rapidly decreased after ovulation.<BR>The levels of plasma PGF <SUB>2α</SUB> peaked not only in the intact rats but also in the hysterectomized rats at 8 hours after the HCG treatment. But in the ovariectomized rats, this plasma PGF <SUB>2α</SUB> peak at 8 hours disappeared and there was no statistical change of plasma PGF <SUB>2α</SUB> throughout the PMS-HCG treatment. Plasma progesterone gradually increased and reached the maximum at 10 hours after the HCG injection.<BR>These results conclude that the main source of increased plasma PGF <SUB>2α</SUB> during the ovulatory process induced with the PMS-HCG treatment is the ovary, and it is strongly suggested that a rapid increase of PGF <SUB>2α</SUB> in the ovary may play some important role (s) in the ovulatory process.
- 社団法人 日本内分泌学会の論文
著者
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Igarashi Masao
Department Of Obstetrics And Gynecology School Of Medicine Gunma University
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SATO TSUNEHARU
Department of Obstetrics and Gynecology, School of Medicine, University of Gunma
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IESAKA TOSHIKIYO
Department of Obstetrics and Gynecology, Gunma University School of Medicine
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SATO TSUNEHARU
Department of Obstetrics and Gynecology, Gunma University School of Medicine
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IGARASHI MASAO
Department of Obstetrics and Gynecology, Gunma University School of Medicine
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