Effect of Prostaglandin F2α upon Ovulation and LH, FSH and Prolactin Secretion in Chlorpromazine Blocked Rats
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概要
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The ovulation-inducing and LH, FSH and prolactin releasing activities of prostaglandin F<SUB>2α</SUB> (PG F<SUB>2α</SUB>) were investigated, using the female rats which had ovulation blocked by chlorpromazine (CPZ). Serum LH, FSH and prolactin concentrations were measured with NIAMD-rat-radioimmunoassay kits. The number of ova present in the fallopian tubes was investigated microscopically. Subcutaneous injection of 0.4-1.6mg of PG F<SUB>2α</SUB> at 3:00 p.m. to CPZ-blocked proestrous rats induced ovulation in 80% of the animals during presumptive estrus. However, the percentage of ovulating rats was reduced in 40-60% of the animals when the same doses of P F<SUB>2α</SUB> were injected intravenously. All control animals receiving the vehicle alone did not ovulated. The number of ova was not related to the dose of PG F<SUB>2α</SUB>, but the percentage of ovulating rats was.<BR>The serum LH peak was observed 10min after the intravenous injection and 60-180min after the subcutaneous injection of PG F<SUB>2α</SUB>. The peak in serum FSH and prolactin occurred simultaneously 180min after both subcutaneous and intravenous injection of PG F<SUB>2α</SUB>.<BR>It is concluded from these data that PG F<SUB>2α</SUB>, at dose levels used, may directly affect the hypothalamo-pituitary axis and consequently induce ovulation. These results further support the conception that the prostaglandins (PGs) have a central effect stimulating LH, FSH and prolactin release from the anterior pituitary.
- 社団法人 日本内分泌学会の論文
著者
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TAYA Kazuyoshi
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu Uni
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Igarashi Masao
Department Of Obstetrics And Gynecology School Of Medicine Gunma University
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SATO TSUNEHARU
Department of Obstetrics and Gynecology, School of Medicine, University of Gunma
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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SATO TSUNEHARU
Department of Obstetrics and Gynecology, Gunma University School of Medicine
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IGARASHI MASAO
Department of Obsterics and Gynecology, Gunma University School of Medicine
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IGARASHI MASAO
Department of Obstetrics and Gynecology, School of Medicine, University of Gunma
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TAYA KAZUYOSHI
Department of Obstetrics and Gynecology, School of Medicine, University of Gunma
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