The Secretory Pattern and Source of Immunoreactive Prolactin in Pregnant African (Loxodonta africana) and Asian (Elephas maximus) Elephants
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概要
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The objective of the present study was to define the secretion of prolactin (PRL) in pregnant African and Asian elephants. Levels of immunoreactive (ir-) PRL in serum and placental homogenates were measured by a heterologous radioimmunoassay (RIA) based on an ovine and human RIA system, and the localization of immunoreactive (ir-) PRL in the placenta was detected by immunohistochemistry using anti-human PRL. Circulating ir-prolactin clearly showed a biphasic pattern during pregnancy in African and Asian elephants. Serum levels of ir-PRL started to increase from the 4-6th month of gestation and reached the first peak level around the 11-14th month. A second peak of circulating ir-PRL levels was observed around the 18-20th month of gestation followed by an abrupt decline after parturition. In contrast, in a case of abortion of an African elephant, the second peak of ir-PRL was not observed, and the levels remained low for about four months until parturition. The weight of the fetus delivered at the 17th month of gestation was 23.5 kg, which was quite small compared with normal fetuses in previous reports. Ir-PRL was detected in placental homogenates, and immunolocalization was observed in trophoblasts in both the African and Asian elephants, indicating that the placenta is the source of ir-PRL during pregnancy in elephants. The present results clearly demonstrated that circulating ir-PRL shows a biphasic pattern during normal pregnancy and that the placenta appears to be an important source of circulating ir-PRL during pregnancy in both African and Asian elephants.
著者
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KAEWMANEE Saroch
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu Univ
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Hildebrandt Thomas
Leibniz Institute For Zoo And Wildlife Research
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Watanabe Gen
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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Yamamoto Tatsuya
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Nagaoka Kentaro
Laboratory Of Animal Breeding Faculty Of Agriculture The University Of Tokyo
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Taya Kazuyoshi
Department Of Basic Veterinary Science United Graduate School Of Veterinary Sciences Gifu University
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LUEDERS Imke
Leibniz Institute for Zoo and Wildlife Research
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WIBBELT Gudrun
Leibniz Institute for Zoo and Wildlife Research
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SHIINA Osamu
Ehime Tobe Zoological Park
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MOURI Yasushi
Ehime Tobe Zoological Park
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SUGIMURA Keisuke
Municipal Kobe Oji Zoo
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SAKAMOTO Sayuri
Ichihara Elephant Kingdom
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Yamamoto Yuki
Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu University
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Yuto Natsuki
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technology
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Yamamoto Tatsuya
Department Of Basic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu University
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TAYA Kazuyoshi
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
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NAGAOKA Kentaro
Laboratory of Animal Breeding and Reproduction, University of Tokyo, Tokyo 113-8657, Japan
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NAGAOKA Kentaro
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan
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YAMAMOTO Yuki
Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
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SHIINA Osamu
Ehime Tobe Zoological Park, Ehime 791-2191, Japan
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SUGIMURA Keisuke
Municipal Kobe Oji Zoo, Hyogo 657-0838, Japan
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Nagaoka Kentaro
Laboratory of Animal Breeding and Reproduction, University of Tokyo
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