Mechanism of Constipation in Familial Amyloid Polyneuropathy: a Case Report

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概要

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• Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a prolonged colonic transit time, a low anal pressure at rest and upon squeezing, loss of the spontaneous phasic rectal contractions, and weak abdominal strain. All these abnormalities suggested a peripheral autonomic dysfunction, corresponding to the enteric neuropathy that was confirmed upon autopsy.

著者

• Hattori Takamichi

  Department Of Neurology Chiba University

• Sakakibara Ryuji

  Department Of Neurology Chiba University

• Yamaguchi Taketo

  Department Of Dentistry Saitama Prefecture Kaikoen

• Liu Zhi

  Department Of Chemical Engineering Tokyo University Of Agriculture And Technology

• Ito Shoichi

  Department Of Agricultural And Resource Economics Faculty Of Agriculture Kyushu University

• Yamamoto Tatsuya

  Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University

• Uchiyama Tomoyuki

  Department Of Materials Science Shizuoka Institute Of Science And Technology

• ITO Takashi

  Department of Advanced Materials Chemistry, Graduate School of Engineering, Yokohama National University

• Higashi Morihiro

  Department of Molecular and Tumor Pathology, Chiba University

• Odaka Takeo

  Department of Gastroenterology, Chiba University

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