A Case of Primary Central Nervous System Lymphoma Presenting Diffuse Infiltrative Luekoencephalopathy

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概要

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• A 58-year-old immunocompetent man gradually developed loss of appetite, cognitive decline, gait disturbances, and personality changes over 4 months. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without mass formation on admission. His condition progressively deteriorated, and we treated him with intravenous high-dose steroids. His symptoms improved rapidly, but exacerbated when therapy was withdrawn. A brain biopsy was performed, and the diagnosis of primary central nervous system lymphoma (PCNSL) was confirmed. He was successfully treated with high-dose methotrexate therapy. Although it is difficult to diagnose PCNSL without mass formation in the early stages, steroid responsiveness is important and brain biopsy is essential for the correct diagnosis of PCNSL.

著者

• Iwadate Yasuo

  Department Of Neurological Surgery Chiba University Graduate School Of Medicine

• Kuwabara Satoshi

  Department Of Neurology Chiba University

• Oide Takashi

  Department Of Diagnostic Pathology Chiba University Graduate School Of Medicine

• Higuchi Yoshinori

  Department Of Internal Medicine And Rheumatology Clinical Research Institute National Hospital Organ

• Ito Shoichi

  Department Of Agricultural And Resource Economics Faculty Of Agriculture Kyushu University

• Yamamoto Tatsuya

  Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University

• Yamamoto Tatsuya

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Kojima Kazuho

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Koibuchi Katsura

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Iwadate Yasuo

  Department of Neurosurgery, Graduate School of Medicine, Chiba University, Japan

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