Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial

スポンサーリンク

概要

• 論文の詳細を見る

• Objective No clinically effective treatment for promoting peripheral axonal regeneration has yet been established. Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin (MeCbl), an analogue of vitamin B12, promotes axonal growth in peripheral nerve injury. We herein assessed the safety and efficacy of an ultra-high dose MeCbl treatment for patients with peripheral neuropathy and chronic axonal degeneration. Methods Fourteen patients with immune-mediated or hereditary neuropathy in the chronic progressive or stable phase were enrolled. MeCbl, 25 mg/day for 10 days followed by monthly 25 mg for 5 months, was intravenously administered. The patients were evaluated before and 1 year following treatment. The primary endpoints were safety and improvement in the Medical Research Council (MRC) sum score in at least two muscles of the 20 muscles. This trial is registered with the University Hospital Medical Information Network (UMIN) Center in Japan under the ID: UMIN000009359. Results There were no adverse effects in twelve of the patients, whereas treatment was discontinued in two patients who had seborrheic dermatitis at 3 months and respiratory tract infection at 2 months, respectively. Therefore, twelve patients were evaluated for the primary outcomes; the MRC sum score was improved in seven of the patients and unchanged or worsened in the remaining five patients. Conclusion Intravenous ultra-high dose MeCbl treatment is a safe and potentially efficacious therapy for patients with peripheral neuropathy and chronic axonal degeneration.

• 一般社団法人 日本内科学会の論文

著者

• Kuwabara Satoshi

  Department Of Neurology Chiba University

• Sekiguchi Yukari

  Department Of Anatomy And Embryology Faculty Of Medicine University Of Tsukuba

• Kaji Ryuji

  Department Of Clinical Neuroscience Institute Of Health Biosciences The University Of Tokushima Graduate School

• Misawa Sonoko

  Department of Neurology, Chiba University School of Medicine

• Beppu Minako

  Department of Neurology, Kobe City Medical Center General Hospital

• Nasu Saiko

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Shibuya Kazumoto

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Isose Sagiri

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Iwai Yuta

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Mitsuma Satsuki

  Department of Neurology, Graduate School of Medicine, Chiba University, Japan

• Arimura Kimiyoshi

  Okatsu Neurology and Rehabilitation Hospital, Japan

関連論文

• Anti-neuronal Antibodies in Acute Pandysautonomia
• Successful Treatment of POEMS Syndrome Complicated by Severe Congestive Heart Failure with Thalidomide
• Multifocal Conduction Blocks in Sarcoid Peripheral Neuropathy
• II F16 A case of familial paroxysmal hypnogenic dyskinesia and sick sinus syndrome with severe abnormality of potassium-conductance in peripheral nerve
• Hemichorea Associated with Ipsilateral Chronic Subdural Hematoma : Case Report
• Failure of Treatment with Anti-VEGF Monoclonal Antibody for Long-standing POEMS Syndrome
• Prevalence and mechanism of urinary dysfunction in Guillain-Barre syndrome
• Magnetic Resonance Imaging of Chiari Malformations
• Morphological Changes of Unmyelinated Nerves in the Cerebral Arteries after Removal of the Pterygopalatine Ganglion : An Electron Microscopic Study
• Cavernous Angioma of the Cerebellum : Case Report
• Huge, Dense, Cystic Craniopharyngioma with Unusual Extensions : Case Report
• Refinement of a locus for autosomal dominant hereditary motor and sensory neuropathy with proximal dominancy (HMSN-P) and genetic heterogeneity
• Moyamoya Disease Associated with Pituitary Adenoma : Report of Two Cases
• Detection of Bone Lesions by CT in POEMS Syndrome
• Intraventricular Hemangiopericytoma : Case Report
• Guillain-Barre Syndrome Following Hand-foot-and-mouth Disease
• Chronic Inflammatory Demyelinating Polyneuropathy Associated with Idiopathic Hemochromatosis
• Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2
• A patient with neuromyelitis optica with positive anti-Ro (SS-A) antibody presenting with intractable hiccup and nausea
• A Case of Primary Central Nervous System Lymphoma Presenting Diffuse Infiltrative Luekoencephalopathy
• Noninvasive Monitoring of β-Cell Mass and Fetal β-Cell Genesis in Mice Using Bioluminescence Imaging
• Prevalence of inositol 1, 4, 5-triphosphate receptor type 1 gene deletion, the mutation for spinocerebellar ataxia type 15, in Japan screened by gene dosage
• Noninvasive Monitoring of β-Cell Mass and Fetal β-Cell Genesis in Mice Using Bioluminescence Imaging
• Anti-Aquaporin-4 Antibody-Seronegative NMO Spectrum Disorder with Baló's Concentric Lesions
• B Cell Aplasia and Hypogammaglobulinemia after Carbamazepine Treatment
• Effects of Carotid Artery Occlusion and Reflow on Cerebral Circulation in Normotensive and Spontaneously Hypertensive Rats
• Basal Ganglia Hyperintensity on T1-weighted Imaging of a Patient with Central Nervous System Metastasis Producing Carcinoembryonic Antigens
• Pseudoperipheral Palsy due to Infarction in the Internal Capsule
• Features of Brain Magnetic Resonance Imaging Diffusion-Weighted Images of Aortogenic Embolic Stroke:– Comparison With Cardioembolic Stroke –
• Investigation of Antimuscarinic Receptor Autoantibodies in Patients with Acquired Idiopathic Generalized Anhidrosis
• Diffuse Neurosarcoidosis Involving Only the Leptomeninges of the Brainstem and Spinal Cord
• Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31
• Eosinophilic Granuloma of the Skull in Identical Twins:—Case Report—
• Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial

もっと見る 閉じる

スポンサーリンク