Anti-neuronal Antibodies in Acute Pandysautonomia
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概要
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We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intravenous immunoglobulin therapy. Thin-layer chromatography (TLC)-immunostaining did not demonstrate any antibodies against gangliosides, but immunoblot analysis showed antibodies against a neuroblastoma cell line, SH-SY5Y, in serum samples. Furthermore, ganglionic acetylcholine receptor autoantibodies were detected in one patient. These findings suggest that neuronal antibodies against the autonomic nervous system play an important role in the pathogenesis of acute pandysautonomia.
著者
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Matsui Naoko
Department Of Cell Biology Institute Of Development Aging And Cancer Tohoku University
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Yokoi Kenji
Department Of Applied Physics National Defense Academy
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OHSHIMA Yasushi
Department of Internal Medicine, Anan Kyoei Hospital
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Mitsui Takao
Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O
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Matsumoto Toshio
Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O
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Kaji Ryuji
Department Of Clinical Neuroscience Institute Of Health Biosciences The University Of Tokushima Graduate School
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Kunishige Makoto
Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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Yagi Fumikazu
Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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Vernino Steven
Department of Neurology, University of Texas Southwestern Medical Center
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MATSUMOTO Toshio
Department of Medicine and Bioregulatory Science (the First Department of Internal Medicine), School of Medicine, The University of Tokushima
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Ohshima Yasushi
Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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MITSUI Takao
Department of Medicine and Bioregulatory Science (the First Department of Internal Medicine), School of Medicine, The University of Tokushima
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Mitsui Takao
Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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