Dermatomyositis with Peripheral Nervous System Involvement : Activation of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor (VEGFR) in Vasculitic Lesions

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概要

• 論文の詳細を見る

• We describe two cases of dermatomyositis (DM) with nervous system involvement. Poly neuropathy was observed in both patients, and cerebral vasculitis was suspected in one patient. Histological examination of biopsied specimens of skeletal muscles, skin and sural nerves revealed vasculitis. Furthermore, vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) were overexpressed in vasculitic lesions. Although, VEGF and VEGFRs were not detected in biopsied specimens of skeletal muscle from normal subjects, they were observed in one of two patients with DM who did not exhibit neuropathy. These findings suggest the possibility that VEGF overproduction is associated with development of vasculitis in some cases of DM complicated with peripheral neuropathy.(Internal Medicine 42: 1233-1239, 2003)

• 社団法人 日本内科学会の論文
• 2003-12-01

著者

• Matsumoto Toshio

  First Department of Internal Medicine, University of Tokushima, School of Medicine

• Matsui Naoko

  First Department Of Internal Medicine Tokushima University

• Endo Itsuro

  First Department Of Internal Medicine Tokushima University

• Oshima Yasushi

  First Department Of Internal Medicine Tokushima University

• MITSUI Takao

  First Department of Internal Medicine, Tokushima University

• KUNISHIGE Makoto

  First Department of Internal Medicine, Tokushima University

• Mitsui Takao

  First Department Of Internal Medicine Tokushima University

• Mitsui Takao

  First Department Of Internal Medicine School Of Medicine The University Of Tokushima

• Kunishige Makoto

  First Department Of Internal Medicine Tokushima University

• Mitsui Takao

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Matsumoto Toshio

  First Department Of Internal Medicine Tokushima University

• Matsumoto T

  First Department Of Internal Medicine University Of Tokushima School Of Medicine

• Matsumoto Toshio

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Matsumoto Toshio

  First Department Of Internal Medicine And The First Department Of Pathology School Of Medicine Unive

• Oshima Y

  First Department of Internal Medicine, Tokushima University

• Kunishige M

  First Department of Internal Medicine, Tokushima University

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