Diurnal Fluctuation of Edema Synchronized with Plasma VEGF Concentration in a Patient with POEMS Syndrome

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概要

• 論文の詳細を見る

• A case of POEMS syndrome in a 49-year-old Japanese woman is reported. The patient exhibited prominent edema in her legs at night, but her edema usually improved by the following morning. The plasma concentrations of VEGF in the patient showed diurnal fluctuations; plasma VEGF levels peaked at night and decreased in the daytime. Immunocytochemical study demonstrated the expression of VEGF in IgA- and λ-positive plasma cells in bone marrow. The results indicate that VEGF was produced at least by plasma cells and that VEGF production was regulated by circadian rhythm in synchronization with the development of edema.(Internal Medicine 41: 1196-1198, 2002)

• 社団法人 日本内科学会の論文
• 2002-12-01

著者

• Matsumoto Toshio

  Department of Medicine and Bioregulatory Sciences, IHBS, the University of TOKUSHIMA Graduate school

• ENDO ITSURO

  Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medica

• Oshima Yasushi

  Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medi

• Matsumoto Toshio

  Department Of Medicine And Bioregulatory Sciences Graduate School Of Medical Sciences University Of

• Matsumoto T

  Department Of Applied Chemistry Faculty Of Engineering Gunma University

• Endo Itsuro

  First Department Of Internal Medicine Tokushima University

• Endo Itsuro

  Department Of Medicine And Bioregulatory Sciences Institute Of Health Biosciences The University Of

• Nishino Maki

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Nishino Maki

  Department Of Internal Medicine Okawa General Hospital

• Oshima Yasushi

  First Department Of Internal Medicine Tokushima University

• Oshima Yasushi

  Department Of Orthopaedic Surgery Faculty Of Medicine The University Of Tokyo

• Mitsui Takao

  First Department Of Internal Medicine Tokushima University

• MITSUI Takao

  Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medici

• Mitsui Takao

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Mitsui Takao

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Oshima Y

  Department Of Chemical System Engineering School Of Engineering The University Of Tokyo

• Matsumoto Toshio

  First Department Of Internal Medicine Tokushima University

• Matsumoto Toshio

  Department Of Medicine And Bioregulatory Science(the First Department Of Internal Medicine) School O

• Mitsui Takeo

  Department of Medicine and Bioregulatory Science(the First Department of Internal Medicine), School of Medicine, The University of Tokushima

• ENDO Itsuro

  Department of Medicine and Bioregulatory Science (the First Department of Internal Medicine), School of Medicine, The University of Tokushima

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