Localization of Estrogen Receptors α and β in the Articular Surface of the Rat Femur
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概要
- 論文の詳細を見る
It has been suggested that the degradation of the articular cartilage and osteoarthritis (OA) are associated with gender and the estrogen hormone. Although many investigators have reported the presence of the estrogen receptors (ERs) α and β in the articular cartilage, the localization of these receptors and the difference in their in vivo expression have not yet been clearly demonstrated. We performed immunofluorescence staining of ERα and ERβ to elucidate the localization of the ERs and to note the effects of gender and the aging process on these receptors. The results revealed that ERα and ERβ were expressed in the articular cartilage and subchondral bone layers of adult rats of both sexes. We also observed the high expression of these receptors in immature rats. In contrast, their expression levels decreased in an ovariectomised model, as a simulation of postmenopause, and in aged female rats. Therefore, this study suggests the direct effects of estrogen and ER expression on articular surface metabolism.
- 日本組織細胞化学会の論文
著者
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MATSUDA Ken-ichi
Department of Cell Biology, Institute of Development, Aging and Cancer
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Kubo Toshikazu
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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WATANABE NOBUYOSHI
Department of Orthopaedic Surgery, Kyoto Kujo Hospital
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Kawata Mitsuhiro
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
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Matsuda Ken-ichi
Department Of Anatomy And Neurobiology Graduate School Of Medical Science Kyoto Prefectural Universi
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Oshima Yasushi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medi
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Yoshida Atsuhiko
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medi
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Kawata Mitsuhiro
Department Of Anatomy And Neurobiology Graduate School Of Medical Science Kyoto Prefectural Universi
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Oshima Yasushi
Department Of Orthopaedic Surgery Faculty Of Medicine The University Of Tokyo
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Kubo Toshikazu
Department Of Orthopaedic Surgery Kyoto Prefectural University Of Medicine
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Watanabe Nobuyoshi
Department Of Orthopaedic Surgery Kyoto Kujo Hospital
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Watanabe Nobuyoshi
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Yoshida Atsuhiko
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Oshima Yasushi
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Kubo Toshikazu
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Watanabe Nobuyoshi
Department of Engineering Science, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan
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OSHIMA Yasushi
Department of Medicine and Bioregulatory Science (the First Department of Internal Medicine), School of Medicine, The University of Tokushima
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