Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
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概要
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We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an important role in baroreflex function.
著者
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Chishaki Akiko
Department of Health Sciences, School of Medicine, Kyushu University
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Honda Kenji
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Takano Yukio
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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SAITO Ryo
Department of Physics, Graduate School of Science, The University of Tokyo
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Nakamura Yusuke
Department of Biochemistry, Cancer Institute
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Masuda Tomoharu
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Hirabara Yasutoshi
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Tsuruhisa Mai
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Miyakawa Masayuki
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, J
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Sakamoto Hirotaka
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
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Kawata Mitsuhiro
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
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