The Role of Spinal Muscarinic Acetylcholine Receptors in Clonidine-Induced Anti-nociceptive Effects in Rats(Pharmacology)

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概要

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• We have examined the effects of intrathecal (i.t.) injection of the muscarinic acetylcholine receptor antagonist atropine on the clonidine-induced nociceptive effect in formalin-induced nociception in rats. The injection of 5% formalin into the hind paw caused biphasic nociceptive responses, and i.t. injection of clonidine inhibited both phases of the nociceptive response in a dose-dependent manner. Pretreatment with atropine (i.t.) only partially inhibited the nociceptive effect of clonidine. These results suggest that the nociceptive effect of clonidine in the rat formalin model may be at least partly mediated by muscarinic acetylcholine receptors in the spinal cord.

• 公益社団法人日本薬学会の論文
• 2003-08-01

著者

• Honda Kenji

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Kamiya H

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University

• Takano Y

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Takano Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• IBUKI Takae

  Department of Anesthesiology, Graduate School of Medical Science, Kyoto Prefectural University of Me

• Takano Yukio

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Ibuki Takae

  Department Of Anesthesiology Kyoto Prefectural University Of Medicine

• Ibuki Takae

  Department Of Anesthesiology Graduate School Of Medical Science Kyoto Prefectural University Of Medi

• Honda Kenji

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda K

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• KAMIYA Hiro-o

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Honda K

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Phamaceutical Sciences Fukuoka University

• MURAO Namiko

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University

• Kamiya Hiro-o

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Kenji

  Department Of Chemistry Toho University

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Murao Namiko

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University

• Ibuki Takae

  Department of Anatomy, Kyoto Prefectural University of Medicine

• KAMIYA Hiro-o

  Department of Pharmaceutical Sciences, Fukuoka University

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