Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies

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概要

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• Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoracic burn injuries remotely induce hindpaw hyperalgesia during the healing stage. During 2-3 weeks after thoracic burn injury when the skin was regenerating from the wound, we observed by formalin test that the number of flinching behaviors significantly increased and simultaneously we observed by von Frey test that rats developed mechano-hyper-algesia in the foot. In the dorsal horn of the lumber spinal cord in burn injured rats, c-Fos expression was significantly augmented after plantar formalin injection. The expression of μ-opioid receptor in burn injured rats was significantly decreased compared with that in sham operated rats. The expression of substance P and CGRP in the lumbar dorsal horn was not different between burn and sham operated animals. We also observed that intrathecal administration of glutamate receptor antagonists(MK801 and CNQX)but not cyclooxigenase-2 an-tagonist(NS-398)reversed the threshold of von Frey test on the foot up to the control level at 2 weeks after injury. Collectively, we analyzed a new pain model showing foot hyperalgesia after thoracic burn injury and demonstrated that neurotransmission of glutamate was enhanced at the lumbar spinal cord level by immunocytochemistry and intrathecal administration of NMDA and non NMDA antagonists. Although the precise mechanism of how remote hyperalgesia at the healing stage developed in this model remains to be confirmed, substances such as trophic factors released from the regenerating skin may cause systemic hyperalgesia including in the foot.

• 日本組織細胞化学会の論文

著者

• Hirose Munetaka

  Department of Anesthesiology and Reanimatology, University of Fukui, Faculty of Medical Sciences, Ja

• Hirose Munetaka

  京都府立医科大学 麻酔科

• TANAKA Masaki

  Department of Health Care Chemistry, College of Environmental Health, Azabu University

• Tanaka M

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• Tanaka Masaki

  京都府立医科大学 第2解剖

• IBUKI Takae

  Department of Anesthesiology, Graduate School of Medical Science, Kyoto Prefectural University of Me

• UEDA Masashi

  Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer

• Naruse Yoshihisa

  Department of Cardiology, Seirei Mikatahara Hospital

• Ibuki Takae

  Department Of Anesthesiology Kyoto Prefectural University Of Medicine

• Ibuki Takae

  Department Of Anesthesiology Graduate School Of Medical Science Kyoto Prefectural University Of Medi

• Ibata Yasuhiko

  Office Of The President Kyoto Prefectural University Of Medicine

• Ibata Y

  Kyoto Prefectural Univ. Medicine Kyoto Jpn

• Ibata Yasuhiko

  Second Department Of Anatomy Kyoto Prefectural University Of Medicine

• Ibata Yasuhiko

  Department Of Anatomy Kyoto Prefectural University Of Medicine

• Ibata Yasuhiko

  Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine

• Naruse Yoshihisa

  Department Of Anatomy & Neurobiology Kyoto Prefectural University Of Medicine

• TAKEI Nobuyuki

  Department of Molecular Neurobiology, Brain Research Institute, Niigata University

• Ibata Yasuhiko

  2nd Department Of Anatomy Kyoto Prefectural University Of Medicine

• Ikeda Teru

  Department Of Anatomy & Neurobiology Kyoto Prefectural University Of Medicine

• Ueda Masashi

  Department Of Anesthesiology Kyoto Prefectural University Of Medicine

• Tanaka Masaki

  Department Of Health Care Chemistry College Of Environmental Health Azabu University

• Takei Nobuyuki

  Molecular Neurobiology Brain Research Institute Niigata University

• Takei Nobuyuki

  Department Of Molecular Neurobiology Brain Research Institute Niigata University

• Ibata Yasuhiko

  Dept.of Anatomy And Neurobiology Kyoto Prefectural Univ.of Medicine

• Takei N

  Molecular Neurobiology Brain Research Institute Niigata University

• Ueda Masashi

  Department Of Anesthesiology And Reanimatology Faculty Of Medical Sciences University Of Fukui

• Hirose Munetaka

  Department Of Anesthesiology And Reanimatology Faculty Of Medical Sciences University Of Fukui

• Tanaka Masaki

  Department Of Anatomy & Neurobiology Kyoto Prefectural University Of Medicine

• Ibuki Takae

  Departments Of Anesthesiol. Kyoto Prefectural University Of Medicine

• Ibuki Takae

  Department of Anatomy, Kyoto Prefectural University of Medicine

• HIROSE Munetaka

  Department of Anesthesia and Pain Clinic, Kusatsu General Hospital

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