Age-related Changes in Astrocytes and Microvasculature in the Median Eminence of the Rat
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概要
- 論文の詳細を見る
Age-related changes in astrocytes, tanycytes and the microvasculature were investigated in the median eminence (ME) of the anterior hypothalamo-hypophyseal system of 2- and 24-month old rats by means of immunocytochemistry and scanning electron microscopy. A computer-assisted image processing system showed a significant increase of the glial fibrillary acidic protein (GFAP) immunoreactivity in the internal layer (IL) and the perivascular region of the external layer (EL) of the ME with age. However, no remarkable changes in either layer could be detected employing vimentin immunoreactivity. An immunoelectron microscopic study revealed that the number of the GFAP-immunoreactive processes markedly increased with age in regions surrounding the capillaries of the EL. Therefore, it may be considered that, in both layers, the astrocytic cell bodies and associated glial processes exhibit a significant increase with age. Investigation of the microvasculature under a scanning electron microscope demonstrated the development and the sinusoidal progress of the external capillary plexus with age, but these changes were not observed in the internal capillary network of the ME. In conclusion, the results of the present study showed a close correlation between the increase of the GFAP-immunoreactive astrocytes and the development of the external capillary plexus. In addition, there was a close correlation between the increase in the GFAP-immunoreactive astrocytes and the sinusoidal progress.
- 日本組織細胞化学会の論文
著者
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Tanaka Yuetsu
Ryukyu Univ.
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Suwa Fumihiko
Department of Anatomy, Osaka Dental University
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ISHIHARA Akihiko
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University
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Tamada Yoshitaka
Department of Anatomy, Osaka Dental University
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Suwa F
Department Of Anatomy Osaka Dental University
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Suwa Fumihiko
Department Of Anatomy Osaka Dental University
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Suwa Fumihiko
大阪歯科大学 生化学
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Suwa Fumihiko
大阪歯科大学 歯学研究科歯周病学
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Tamada Yoshitaka
大阪歯科大学 解剖学
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Tamada Y
Department Of Anatomy Osaka Dental University
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Tamada Yoshitaka
大阪歯科大学 解剖学-組織学
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Ibata Yasuhiko
Office Of The President Kyoto Prefectural University Of Medicine
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Ibata Y
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Ibata Yasuhiko
Second Department Of Anatomy Kyoto Prefectural University Of Medicine
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Suwa Fumihiko
Department Of Oral Anatomy Osaka Dental University
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Ishihara A
Kyoto Univ. Kyoto Jpn
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Ibata Yasuhiko
Kyoto Prefectural University Of Medicine
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Ibata Yasuhiko
2nd Department Of Anatomy Kyoto Prefectural University Of Medicine
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UEMURA Mamoru
Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
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IKE Hiromi
Department of Anatomy, Osaka Dental University
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Ike Hiromi
Department Of Anatomy Osaka Dental University
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Tamura Yasuhisa
Department Of Anatomy And Cell Science Kansai Medical University
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石原 昭彦
Laboratory Of Neurochemistry Graduate School Of Human And Environmental Studies Kyoto University
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Tamada Yoshitaka
Department Of Anatomy And Cell Science Kansai Medical University
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Tamada Yoshitaka
Dept.of Anatomy And Neurobiology Kyoto Prefectural Univ.of Medicine
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Ishihara Akihiko
Second Department Of Internal Medicine The University Of Tokushima
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Ishihara Akihiko
Laboratory Of Neurochemistry Faculty Of Integrated Human Studies Kyoto University
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Uemura Mamoru
Department Of Anatomy Osaka Dental University
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Ibata Yasuhiko
Dept.of Anatomy And Neurobiology Kyoto Prefectural Univ.of Medicine
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Ishihara Akihiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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Uemura Mamoru
Department of Anatomy, Osaka Dental University
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