Wound healing on palatine mucosa in the type 2 diabetes mellitus model rats
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概要
- 論文の詳細を見る
We analyzed histological changes during spontaneous healing in palatine mucosa lesions and examined whether there were any differences in healing between GK (diabetes group) and normal Wistar (control group) rats. Forty-three 8-week-old male rats (21 in each group) were used in this study. We created a cylindrical lesion 1.5mm in diameter in the palatine mucosa of the right maxillary first molar by removing all of the soft tissue. One Wistar rat was not given a lesion and was observed about normal histological structures. Immediately and one day after surgery, the experimental cavities of both groups were filled with blood clots. The mucosal epithelium converged on day 3 after surgery in the control group and on day 7 in the diabetes group. Granulation tissue was seen on day 5 in the control group and on day 7 in the diabetes group. Collagen fibers appeared on day 7 in the controls and on day 14 in the diabetes group. We observed the formation of sequestrum on days 14 and 28 in one of six rats in the control group and five of six in the diabetes group. Our results demonstrate that wound healing was delayed in the diabetes group compared with the controls. Furthermore, sequestrum formation occurred at a higher rate in the diabetes group.
著者
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Takemura Akimichi
Department of Anatomy, Osaka Dental University
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Suwa Fumihiko
Department of Anatomy, Osaka Dental University
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Suwa F
Department Of Anatomy Osaka Dental University
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Suwa Fumihiko
Department Of Anatomy Osaka Dental University
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Suwa Fumihiko
大阪歯科大学 生化学
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Suwa Fumihiko
中華人民共和国
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Suwa Fumihiko
大阪歯科大学 歯学研究科歯周病学
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Suwa Fumihiko
Department Of Oral Anatomy Osaka Dental University
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Takemura Akimichi
Department Of Anatomy Osaka Dental University
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Takemura Akimichi
Osaka Dental Univ. Osaka Jpn
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EHARA Daisuke
Graduate School of Dentistry (Anatomy), Osaka Dental University
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Ehara Daisuke
Graduate School Of Dentistry (department Of Anatomy) Osaka Dental University
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