Healing of tooth extraction socket after bisphosphonate pre-dosage in ovariectomized rats

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We investigated the effect of risedronate pre-dosage on healing of the tooth extraction socket in ovariectomized rats. The formation of new bone and osteoid tissue was examined over time using histological findings and statistical processing. Thirty-six, 8 weeks old female Wistar rats were divided into: a sham operation (Sham) group, an ovariectomized (OVX) group, and a risedronate pre-dosage after ovariectomy (Ris) group of 12 animals each. On days 3, 7, 14 and 28 after tooth extraction, we measured the percentage of the area of new bone, and the percentage of the area of new bone occupied by osteoid. We found that the percentage new bone formation was significantly lower in ovariectomized rats than in the non-ovariectomized animals, throughout the study regardless of whether risedronate was injected. The effect of risedronate pre-dosage in ovariectomized rats was not apparent until 7 days after the extraction, and it increased the percentage of the amount of mature bone to that of new bone formed within the extraction socket at 14 days. These results suggest that risedronate pre-dosage affects healing of the extraction socket in ovariectomized rats.