Growth-Related Changes in Skeletal Muscle Fiber Type and Insulin Resistance in Diabetic Otsuka Long-Evans Tokushima Fatty Rats
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概要
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We investigated whether a relationship exists between the fiber type distribution in skeletal muscles and the insulin resistance of different ages of diabetic rats. The fiber type distributions of the slow soleus and fast plantaris muscles in 5-, 9-, and 21-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rats as an animal model of spontaneous type 2 diabetes mellitus were examined and compared with those in age-matched non-diabetic Long-Evans Tokushima Otsuka (LETO) rats. In the soleus muscle, a higher percentage of type I fibers was observed in the 9- and 21-week-old OLETF rats compared with the age-matched LETO rats, and there were no type IIA fibers remaining in the soleus muscle of the OLETF rats. In the plantaris muscle, a lower percentage of type IIA fibers and a higher percentage of type IIB fibers were observed in the 9- and 21-week-old OLETF rats compared with the age-matched LETO rats. In addition, a lower percentage of type I fibers in the plantaris muscle was observed in the 9-week-old OLETF rats compared with the age-matched LETO rats, and there were no type I fibers in the plantaris muscle of the 21-week-old OLETF rats. All 20-week-old OLETF rats showed serum insulin concentrations of more than 20 ng/ml. The present study suggests that insulin resistance and impaired glucose tolerance from altered muscle fiber type are linked to the cause of diabetes.
- 日本組織細胞化学会の論文
著者
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ADACHI Tetsuya
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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Seino Yutaka
Department of Cardiology, Kansai Electric Power Hospital
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Seino Y
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine:kansai El
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ISHIHARA Akihiko
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University
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TSUDA Kinsuke
Department of Human and Environmental Sciences, Graduate School of Human and Environmental Studies
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Adachi T
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Adachi Tetsuya
Department Of Clinical And Laboratory Medicine Akita University School Of Medicine
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TSUDA Kinsuke
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
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Adachi T
Laboratory Of Metabolism Kyoto University Graduate School Of Human And Environmental Studies
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Ishihara A
Kyoto Univ. Kyoto Jpn
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YASUDA Koichiro
Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University
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SHIHARA NOBUYUKI
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto university
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石原 昭彦
Laboratory Of Neurochemistry Graduate School Of Human And Environmental Studies Kyoto University
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Kano-ishihara Tomomi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Ishihara Akihiko
Second Department Of Internal Medicine The University Of Tokushima
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Ishihara Akihiko
Laboratory Of Neurochemistry Faculty Of Integrated Human Studies Kyoto University
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Seino Y
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
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Seino Yutaka
Department Of Cardiology Kansai Electric Power Hospital
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Yasuda K
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Tsuda Kinsuke
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Tsuda Kinsuke
Graduate School Of Human Science Kyoto University
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Tsuda Kinsuke
Kyoto Univ. Kyoto Jpn
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Seino Yutaka
Division Of Diabetes And Clinical Nutrition Kansai-denryoku Hospital
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Shihara Nobuyuki
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Tsuda Kinsuke
Department Of Human And Environmental Sciences Graduate School Of Human And Environmental Studies
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Ishihara Akihiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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