Administration of Perilla Oil Coated with Calshell Increases Glucagon-Like Peptide Secretion(Pharmacology)
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概要
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Recently, we found that unsaturated long-chain fatty acids (such as α-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as a-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1,14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.
- 2008-05-01
著者
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ADACHI Tetsuya
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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Hirasawa A
Department Of Gynecology Keio University Hospital
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Hirasawa Akira
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Hirasawa Akira
京都大学 薬学研究科ゲノム創薬科学
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Hirasawa A
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Hirasawa Akira
Department Of Gynecology Keio University Hospital
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Adachi T
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Adachi Tetsuya
Department Of Clinical And Laboratory Medicine Akita University School Of Medicine
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TSUDA Kinsuke
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
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Adachi T
Laboratory Of Metabolism Kyoto University Graduate School Of Human And Environmental Studies
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Tsujimoto Gozoh
Department Of Molecular And Cellular Pharmacology National Children's Medical Research Center
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Children 's Medical Research Center
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YANAKA Hiroyuki
KITII Co., Ltd.
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KANAI Hitoshi
KITII Co., Ltd.
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NOZAKI Mayu
KITII Co., Ltd.
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TAKAHARA Yoshiyuki
Pharma Frontier Co., Ltd.
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TSUDA Mariko
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
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JONOUCHI Tatsuya
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto Univ
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Kano-ishihara Tomomi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Nozaki Mayu
Kitii Co. Ltd.
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Tsuda Mariko
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Kanai Hitoshi
Kitii Co. Ltd.
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Yanaka Hiroyuki
Kitii Co. Ltd.
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Jonouchi Tatsuya
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Takahara Yoshiyuki
Pharmafrontier Co. Ltd.
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Hirasawa Akira
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Higashiguchi Atsushi
Department Of Pathology Keio University School Of Medicine
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Tsuda Kinsuke
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Tsuda Kinsuke
Graduate School Of Human Science Kyoto University
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Tsuda Kinsuke
Kyoto Univ. Kyoto Jpn
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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