New Frontiers in Gut Nutrient Sensor Research: Free Fatty Acid Sensing in the Gastrointestinal Tract
スポンサーリンク
概要
- 論文の詳細を見る
Utilizing the human genome database, the recently developed G-protein–coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.
著者
-
HARA Takafumi
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
-
TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
-
Hirasawa Akira
The Department Of Hematology Yokohama Rosai Hospital For Labour Welfare Corporation
-
Hirasawa Akira
京都大学 薬学研究科ゲノム創薬科学
-
Hirasawa A
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
-
Hirasawa Akira
Department Of Gynecology Keio University Hospital
-
Miyauchi Satoshi
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto Univ
-
Ichimura Atsuhiko
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto Univ
-
Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
-
Hirasawa Akira
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
-
Higashiguchi Atsushi
Department Of Pathology Keio University School Of Medicine
-
Hara Takafumi
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
-
Miyauchi Satoshi
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
-
Miyauchi Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
-
Ichimura Atsuhiko
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
関連論文
- New Frontiers in Gut Nutrient Sensor Research: Free Fatty Acid Sensing in the Gastrointestinal Tract
- Free Fatty Acid Receptors and Drug Discovery(Physiology and Pharmacology of the Gut Nutrient Perception)
- Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer
- Outpatient clinic for genetic counseling and gene testing of retinoblastoma
- Angiotensin II Type 1-Receptor Antagonist Candesartan Cilexitil Prevents Left Ventricular Dysfunction in Myocardial Infarcted Rats
- Doppler Echocardiographic Assessment and Cardiac Gene Expression Analysis of the Left Ventricle in Myocardial Infarcted Rats
- Effect of Manidipine Hydrochloride, a Calcium Antagonist, on Isoproterenol-Induced Left Ventricular Hypertrophy
- -P613- Calcium channel antagonist prevents cardiac hypertrophy induced by isoproterenol(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0907- The effect of TCV-116, angiotensin II type I receotor antagonist, ont the cardiac phenotype and extracelullar matrix in left ventricular remodeling after myocardial infarction.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCU
- -0669- Isosorbide Dinitrate Suppresses Protooncogene Expression on Ischemia-Reperfusion Injury(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- The role of angiotensin II type l receptor to the left ventricular remodeling after myocardial infarction
- Protooncogene expression on ischemia-reperfusion injury
- High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers
- An Adult Diagnosed as Hyper-IgM Immunodeficiency Syndrome
- Administration of Perilla Oil Coated with Calshell Increases Glucagon-Like Peptide Secretion(Pharmacology)
- Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot
- New Topics in Vasopressin Receptors and Approach to Novel Drugs : Preface
- Modulation of Angiotensin II Type 1 Receptor mRNA Expression in Human Blood Cells: Comparison of Platelets and Mononuclear Leucocytes
- Effect of the New Class III Antiarrhythmic Drug MS-551 and d-Sotalol on Canine Coronary Ligation-Reperfusion Ventricular Arrhythmias
- Successful Treatment of Listerial Brain Abscess : A Case report and Literature Review
- Cellular Expressions and Serum Concentrations of Fas Ligand and Fas Receptor in Patients With Infectious Mononucleosis
- Differentially Regulated Genes as Putative Targets of Amplifications at 20q in Ovarian Cancers
- Gene Expression Profile in Experimental Mesangial Proliferative Glomerulonephritis
- Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)
- Recent Progress in α_1-Adrenoceptor Pharmacology
- Two Japanese kindreds occurring endometrial cancer meeting new clinical criteria for hereditary non-polyposis colorectal cancer (HNPCC), Amsterdam Criteria II
- Association of HNPCC and endometrial cancers
- Two Soluble Forms of β1,4-Galactosyltransferase Released from Ovarian Cancer Cells and from COS-1 Cells Transfected with its cDNA (Recent Progresses in Carbohydrate Histochemistry)
- CHEMICAL ABORTION IN PATIENTS WITH RECURRENT FETAL LOSS
- Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines
- MicroRNA : Biogenetic and Functional Mechanisms and Involvements in Cell Differentiation and Cancer
- Determination of a Novel Haplotype of β_2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-specific PCR
- SNP genotyping in the β_2-adrenergic receptor by electronic microchip assay, DHPLC, and direct sequencing
- Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis
- Sucrasc-Isomaltase Gene Expression Is Inhibited by Mutant Hepatocyte Nuclear Factor (HNF)-1α and Mutant HNF-1β in Caco-2 Cells
- cDNA microarray analysis of esophageal cancer : discoveries and prospects
- Significance of plasminogen activator inhibitor-1 (PAI-1) expression in ovarian clear cell adenocarcinoma(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Purification and Characterization of Turtle Pepsinogen and Pepsin
- Vascular α1-Adrenoceptor Subtype Selectivity and α1-Blocker-Induced Orthostatic Hypotension
- Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A
- Transcriptome analysis on glucocorticoid-induced apoptosis in leukemia cells
- Pharmacogenomics of Cardiovascular Pharmacology : Development of an Informatics System for Analysis of DNA Microarray Data With a Focus on Lipid Metabolism
- Effect of Chondroitinase ABC on Matrix Metalloproteinases and Inflammatory Mediators Produced by Intervertebral Disc of Rabbit In Vitro
- A novel nonsense mutation of the PEPD gene in a Japanese patient with prolidase deficiency
- Structure and Sequence of the Mouse V1a and V1b Vasopressin Receptor Genes
- Characterization of the Mouse α1D-Adrenergic Receptor Gene
- Naftopidil, Novel α_1-Adrenoceptor Antagonist, Displays Selective Inhibition of Canine Prostatic Pressure and High Affinity Binding to Cloned Human α_1-Adrenoceptors
- Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population
- New Topics in Vasopressin Receptors and Approach to Novel Drugs : Vasopressin and Pain Perception
- Prostaglandin A_2 Acts as a Transactivator for NOR1 (NR4A3) within the Nuclear Receptor Superfamily(Molecular and Cell Biology)
- Successful Treatment of Listerial Brain Abscess : A Case report and Literature Review
- New Frontiers in Gut Nutrient Sensor Research : Free Fatty Acid Sensing in the Gastrointestinal Tract
- Formation of a series of myo-inositol phosphates during growth of rice plant cells in suspension culture
- Electrophysiologic Effects of an Antiarrhythmic Agent, Bidisomide, on Sodium Current in Isolated Rat Ventricular Myocytes: Comparison With Mexiletine and Disopyramide
- Functional Role of Spliced Cytoplasmic Tails in P2X_2-Receptor-Mediated Cellular Signaling
- Detailed Observation of Arterial Healing after Stent Implantation in Swine Arteries by Using Optical Coherence Tomography
- Novel Device That Produces Carbon Dioxide Mist for Myocardial Infarction Treatment in Rats
- The roles of V1a vasopressin receptors in blood pressure homeostasis : a review of studies on V1a receptor knockout mice
- The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice
- MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma
- The first demonstration of CGRP-immunoreactive fibers in canine hearts: Coronary vasodilator, inotropic and chronotropic effects of CGRP in canine isolated, blood-perfused heart preparations.
- Developmental alteration in adrenergic regulation of hepatic glycogen phosphorylase.
- Occurrence of Organic Acids from myo-Inositol in Cultured Rice Cells
- Functional Role of Spliced Cytoplasmic Tails in P2X2-Receptor-Mediated Cellular Signaling
- Effects of a New Antiarrhythmic Drug, SD-3212, on Canine Ventricular Arrhythmia Models.