Characterization of the Mouse α1D-Adrenergic Receptor Gene
スポンサーリンク
概要
- 論文の詳細を見る
α1-Adrenergic receptors (α1-ARs) play critical roles in the regulation of a variety of physiological processes. Increasing evidence suggests that multiple receptor subtypes of α1-ARs regulate these physiological processes. Molecular cloning has identified three distinct cDNAs encoding α1-AR subtypes (α1A, α1B and α1D) that are structurally homologous. Among the α1-AR subtypes, the function of the α1D-AR remains unclear. In order to examine the physiological role of a1D-AR, we cloned and characterized a gene for the mouse α1D-AR. Using a mouse α1D-AR cDNA as a probe, we isolated the gene for the mouse α1D-AR from a mouse genomic library. The α1D-AR consists of two exons and an intron that interrupts the coding region of the putative sixth transmembrane domain. The 5′-flanking region of exon 1 contains neither a TATA box nor a CAAT box but is high in GC content and contains several Sp1 binding sites (GC boxes). This pattern is similar to promoters described for other members of α1-ARs. The untranslated region also contains putative cyclic AMP response elements. Isolation of this gene will allow further investigation, via gene knock-outs and deletion mutants, of the mechanisms of transcriptional regulation and a greater understanding of the physiological role of α1D-AR.
- 社団法人 日本薬理学会の論文
著者
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TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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TANOUE Akito
Department of Pharmacology, National Research Institute for Child Health and Development
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Takahashi Kota
Department of Urology, Graduate School of Medical and Dental Sciences, Niigata Universily
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TAKEDA Masayuki
Department of Urology, Niigata University School of Medicine
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Takahashi Kota
Department Of Nephrology Toho University Medical Center Omori Hospital
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Tsujimoto Gozoh
Department Of Molecular And Cellular Pharmacology National Children's Medical Research Center
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Children 's Medical Research Center
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Tanoue Akito
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Arai Kei
Department Of Urology Faculty Of Medicine Niigata University
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Takeda Masayuki
Department Of Urology Niigata University School Of Medicine
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Arai Kei
Department Of Agriculture University Of Kagoshima
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GODA Nobuhito
Department of Biochemistry and Integrative Medical Biology School of Medicine, Keio University
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Goda Nobuhito
Department Of Biochemistry And Integrative Medical Biology School Of Medicine Keio University
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Takeda Masayuki
Department Of Informatics Kyushu University
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Takeda Masayuki
Department Of Biochemistry And Engineering Faculty Of Engineering Tohoku University
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Takahashi Kota
Department Of Nephrology And Endocrinology University Of Tokyo Graduate School Of Medicine
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Takeda Masayuki
Department Of Urology Faculty Of Medicine Niigata University
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