Prostaglandin A_2 Acts as a Transactivator for NOR1 (NR4A3) within the Nuclear Receptor Superfamily(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Within the nuclear receptor superfamily, Nur77, Nurr1, and NOR1 constitute the nuclear receptor subfamily 4 group A. Modulation of NOR1 function would be therapeutic potential for diseases related to dysfunction of NOR1, including extraskeletal myxoid chondrosarcoma and autoimmune diseases. By screening arachidonate metabolites for their capacity of transcriptional activation, we have identified prostaglandin (PG) A_2 as a transactivator for NOR1. PGA_2 acted as a potent activator of NOR1-dependent transcription through the GAL4-based reporter system. The putative ligand-binding domain (LBD) of the receptor directly bound PGA_2, and LBD-deleted receptor showed little transcriptional activation by PGA_2. Primary cultured spleen cells derived from transgenic mice overexpressing NOR1, showed higher sensitivity to PGA_2 compared to those from wild-type mice. These observations suggest that PGA_2 can serve as a transactivator of NOR1, and thus suggest a possibility of pharmacological modulation of the NOR1 pathways by PGA_2-related compounds.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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MATSUMOTO Kenji
Department of Allergy and Immunology, National Research Institute for Child Health and Development,
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TSUKADA Toshihiko
Tumor Endocrinology Project, National Cancer Center Research Institute
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OHKURA Naganari
Tumor Endocrinology Project, National Cancer Center Research Institute
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SUGITA Yuji
Genox Research Inc.
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Saito Hirohisa
National Research Institute For Child Health And Development
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TSUJIMOTO Gozoh
Graduate School of Pharmaceutical Sciences, Kyoto University
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Ohkura Naganari
National Cancer Center Research Institute
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Ohkura Naganari
Tumor Endocrinology Project National Cancer Center Research Institute
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Graduate School Of Pharmaceutical Sciences Kyoto University
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Tsukada Toshihiko
Tumor Endocrinology Project National Cancer Center Research Institute
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Matsumoto Kenji
Department Of Allergy And Immunology National Research Institute For Child Health And Development
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SAITO Hirohisa
Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama
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HASHIDA Ryoichi
Genox Research Inc.
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KAGAYA Shinji
Genox Research Inc.
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MIYAGAWA Masami
Genox Research Inc.
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Kagaya Shinji
Genox Research Inc.:research Unit For Allergy Transcriptome Research Center For Allergy & Immuno
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Saito Hirohisa
Research Unit For Allergy Transcriptome Research Center For Allergy And Immunology Riken Yokohama In
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Matsumoto Kenji
Department Of Allergy And Immunology National Institute For Child Health & Development
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Matsumoto Kenji
Department of Allergy & Immunology, National Research Institute for Child Health and Development
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