Primary Hepatic Peripheral T-Cell Lymphoma Treated with Corticosteroid
スポンサーリンク
概要
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Primary hepatic lymphoma is a very rare condition, and the majority of the cases reported are of B-cell origin. We report a case of a 65-year-old man with primary hepatic peripheral T-cell lymphoma, not otherwise specified (PTCL-nos) who presented with 15% weight loss and general fatigue over the previous 9 months. Imaging studies and bone marrow examination could not confirm a diagnosis of lymphoma. Liver biopsy was performed because of an elevated soluble interleukin-2 receptor (sIL-2R) level (17,000 U/I) and hepatomegaly. After the diagnosis of primary hepatic PTCL-nos, treatment with low-dose corticosteroid was initiated, and the sIL-2R level decreased. Discontinuation of corticosteroid treatment resulted in the re-elevation of the sIL-2R level, and subsequently, treatment with low-dose corticosteroid was reinitiated. The sIL-2R level decreased rapidly, and the patient is alive with no evidence of lymphoma for 50 months after diagnosis. Thus, we found that a low-dose corticosteroid was effective in the long-term control of the disease, whereas many previous studies reported that primary hepatic PTCL-nos has a poor prognosis.
著者
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ITO Satomi
Department of Hematology, Kanagawa Cancer Center
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Ishigatsubo Yoshiaki
Department Of Internal Medicine And Clinical Immunology Yokohama City University Graduate School Of
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Tomita Naoto
Department Of Hematology Graduate School Of Medicine Yokohama City University
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Fujita Hiroyuki
Department Of Environmental Immuno-dermatology Yokohama City University Graduate School Of Medicine
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Nakajima Yuki
Department of Applied Chemistry, Faculty of Engineering, Saitama University, 255 Shimo-okubo, Sakura, Saitama 338-8570, Japan
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Matsumoto Chihiro
Department of Hematology, Yokosuka City Hospital
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Matsumoto Chihiro
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Miyashita Kazuho
Department of Hematology/Immunology, Fujisawa City Hospital
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Miyashita Kazuho
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Matsumoto Kenji
Department of Allergy & Immunology, National Research Institute for Child Health and Development
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Ito Satomi
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Tomita Naoto
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Fujita Hiroyuki
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
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Oshiro Hisashi
Department of Anatomic Pathology, Tokyo Medical University
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