Expression of Hedgehog Family Genes in the Rat Uterus During Early Pregnancy

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概要

• 論文の詳細を見る

• Hedgehog (Hh) plays a pivotal role in various tissues during embryonic development, tissue homeostasis and tumorigenesis. In mammals, Hh exists in three homologs: Desert hedgehog (Dhh), Indian hedgehog (Ihh) and Sonic hedgehog (Shh). In this study, we cloned full-length cDNAs encoding Dhh and Ihh from the rat uterus. Their amino acid sequences have a high homology with those of the mouse and human. In addition, the changes of Hh gene expression in the rat uterus during early pregnancy were analyzed. The results showed that all three hedgehog mRNAs were detected in the rat uterus at the proestrus stage and during early pregnancy (1.5, 3.5, 5.5, 7.5 days post coitus ;dpc). Ihh mRNA expression varied and peaked at 3.5 dpc in the luminal and glandular epithelium. Expression was decreased on 5.5 dpc with the exception of sustained expression in the glandular epithelium. Despite such Ihh variability, the expressions of Dhh and Shh mRNA remained unchanged. This indicated that Ihh was mainly expressed in the rat uterus during early pregnancy. Moreover, the Hh target gene (glioma-associated oncogene homolog 1; Gli1) was also highly expressed at 3.5 dpc in the epithelium and periepithelial stroma in a manner similar to the temporal pattern of Ihh expression. This suggests that Ihh signaling axis play a role in the rat uterus during early pregnancy. In summary, our results elucidate that Ihh is a predominant Hh protein in the rat uterus during early pregnancy and that other Hhs have the potential to be expressed. This observation will help to elucidate the basic molecular mechanism of rat uterus during early pregnancy.

• 日本繁殖生物学会の論文
• 2008-10-01

著者

• MATSUMOTO Kenji

  Department of Allergy and Immunology, National Research Institute for Child Health and Development,

• Soh T

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Soh Tomoki

  Kyushu Univ. Fukuoka

• Hattori M

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Soh Tomoki

  九州大学 農学研究院動物資源科学

• Soh Tomoki

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Hattori Masa-aki

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Hattori Masa-aki

  Department Of Animal And Marine Bioresource Sciences Faculty Of Agriculture Graduate School Kyushu U

• Aramaki Shinya

  九州大学 農学研究院動物資源科学

• Yamauchi N

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Yamauchi Nobuhiko

  九州大学 農学研究院動物資源科学

• Soh Tomoki

  Laboratory Of Reproductive Physiology And Biotechnology Department Of Animal And Marine Bioresource

• Aramaki Shinya

  Laboratory Of Reproductive Physiology And Biotechnology Department Of Animal And Marine Bioresource

• Aramaki Shinya

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Kubota Kaiyu

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Wood Chris

  Institute of Biotechnology, Universidad Nacional Autonoma de Mexico (UNAM)

• Hattori M

  Kyushu Univ. Fukuoka Jpn

• Hattori M

  Hormone Assay Center Institute Of Endocrinology Gunma University

• Yamauchi N

  Tohoku Univ. Sendai Jpn

• Yamauchi Nobuhiko

  Department Of Animal Reproduction National Institute Of Animal Industry

• WATANABE Ryo

  Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu Univers

• OOZONO Shinji

  Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu Univers

• Wood Chris

  Institute Of Cell Biology And Genetics College Of Life Sciences Zhejiang University

• Soh T

  Laboratory Of Reproductive Physiology And Biotechnology Department Of Animal And Marine Bioresource

• Oozono Shinji

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Matsumoto Kenji

  Department Of Allergy And Immunology National Research Institute For Child Health And Development

• Watanabe Ryo

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Matsumoto Kenji

  Department Of Allergy And Immunology National Institute For Child Health & Development

• Matsumoto Kenji

  Department Of Animal And Marine Bioresource Sciences Graduate School Of Agriculture Kyushu Universit

• Yamauchi Nobuhiko

  Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University

• Matsumoto Kenji

  Department of Allergy & Immunology, National Research Institute for Child Health and Development

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