Young Persimmon Fruits Prevent the Rise in Plasma Lipids in a Diet-Induced Murine Obesity Model(Biopharmacy)
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概要
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The effect of young and mature persimmon fruits on lipid metabolism was investigated in a diet-induced murine obesity model. A commercially purchased high fat diet (Quick Fat, CLEA Japan) was used as the basal diet. Dried and powdered young and mature fruits of two breeds of persimmon, Fuyu-kaki and Hachiya-kaki, were added to the basal diet at a concentration of 10%, respectively. Male C57BL/6 mice (n=4) were divided into five groups and fed the basal diet or one of the persimmon-supplemented basal diets ad libitum for 14 weeks. Diets supplemented with both types of young fruit significantly reduced the rise in plasma lipids, including total cholesterol (p<0.005), triglyceride (p<0.05), and LDL cholesterol (p<0.05), and the effect was almost equal between the two breeds. Real-time RT-PCR revealed that both of these young fruit-supplemented diets equally upregulated expression of the cholesterol 7 alpha-hydroxylase (CYP7A1) gene in the liver by about three-fold (p<0.05). CYP7A1 plays an important role in maintaining cholesterol homeostasis by regulating bile acid synthesis, suggesting that increased conversion of cholesterol to bile acids may have caused the cholesterol-lowering effect of the young fruits. The results indicate that young persimmon fruits are beneficial in the development of preventive and therapeutic agents against dyslipidemia.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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WATANABE Yutaka
Department of Machine Intelligence and Systems Engineering, Graduate School of Engineering, Tohoku U
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MATSUMOTO Kenji
Department of Allergy and Immunology, National Research Institute for Child Health and Development,
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Yokoyama Shin-ichiro
Department of Medicine, Division of Cardiovascular Medicine, Nihon University School of Medicine
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Yokoyama Shin-ichiro
Laboratory Of Microbiology Department Of Public Health Pharmacy Gifu Pharmaceutical University
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MATSUMOTO Kenji
Gifu International Institute of Biotechnology
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Watanabe Yutaka
Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology
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OHYA Masa-aki
Yahiro-sangyo Co., Ltd.
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Ohya Masa-aki
Yahiro-sangyo Co. Ltd.
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Watanabe Yutaka
Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin
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Matsumoto Kenji
Department Of Allergy And Immunology National Research Institute For Child Health And Development
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Yokoyama Shin-ichiro
Gifu Prefectural Research Institute For Bioengineering Department Of Applied Microbiology
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Yokoyama Shin-ichiro
Department Of Advanced Medicine Nihon University School Of Medicine
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Matsumoto Kenji
Gifu Prefectural Research Institute For Bioengineering Department Of Applied Microbiology
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Matsumoto Kenji
Department Of Allergy And Immunology National Institute For Child Health & Development
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Watanabe Yutaka
Department Of Applied Chemistry Faculty Of Engineering Ehime University
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Watanabe Yutaka
Gifu Prefectural Research Institute For Bioengineering Department Of Applied Microbiology
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Matsumoto K
Central Research Laboratory Hitachi Ltd.
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WATANABE Yutaka
Department of Anatomy, Osaka Medical College
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Matsumoto Kenji
Department of Allergy & Immunology, National Research Institute for Child Health and Development
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