Depressor Effect of Wheat Germ Hydrolysate and Its Novel Angiotensin I-Converting Enzyme Inhibitory Peptide, Ile-Val-Tyr, and the Metabplism in Rat and Human Plasma

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概要

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• We report here the antihypertensive effect of wheat germ (WG) hydrolysate and its dominant peptide, Ile-Val-Tyr (IVY), with potent angiotensin I-converting enzyme (ACE) inhibitory activity. The toxicity test of AG50W fraction purified from the WG hydrolysate and IVY in ddy mice recvealed that 1 week median lethal concentrations of AG fraction and IVY were less than 100 and 10 mg/kg, respectively. As a result of an intravenous administration test of both inihibitors in spontaneously hypertensive rat (SHR), the mean arterial blood pressure (MAP) significantly decreased with the dose; the MAP reduction of 10.3 and 19.2 mmHg was observed at a dose of 50 mg/kg of AG fraction and 5 mg/kg of IVY, respectively. In addition to this behavior, the MAP gradually decreased after the 5 mg/kg of IVY injection (time to give a maximum reduction; 8 min), and the reduction was held for 20 min. By using rat and human plasma, IVY was found to be metaboliazed by the action of aminopeptidase in plasma to form a subsequent ACE inhibitor, Val-Tyr (VY). Thus, the intake of OVY as a physiologically functional food would serve in the lowering of blood pressure (BP) by the combined depressor effect of itself and its metabolite after the absorption.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• Matsumoto Kiyoshi

  Institute of Experimental Animals, Shinshu University School of Medicine

• TANAKA Toshiaki

  Research Laboratory of Engineering Materials, Tokyo Institute of Technology

• Matsumoto K

  Division Of Bioscience And Bioenvironmental Sciences Faculty Of Agriculture Graduate School Of Kyush

• OSAJIMA Yutaka

  Department of Food Science and Technology, Faculty of Agriculture, Kyushu University

• Osajima Y

  Kyushu Univ. Fukuoka Jpn

• Osajima Yutaka

  Department Of Bioresources And Biosciences Hiroshima Prefectural University

• Osajima Yutaka

  Kyushu Women's Univ.

• MATSUMOTO Kenji

  Gifu International Institute of Biotechnology

• Matsui T

  Kyushu Univ. Fukuoka Jpn

• Matsui Toshiro

  Fac. Of Agriculture Graduate School Of Kyushu Univ.

• MATSUI Toshiro

  Institute of Food Biotechnology, Division of Bioresource and Bioenvironmental Sciences, Graduate Sch

• LI Chun-Hui

  Institute of Food Biotechnology, Division of Bioresource and Bioenvironmental Sciences, Graduate Sch

• MAKI Tetsuyoshi

  Research Laboratories, Ichiban Shokuhin Co., Ltd.,

• Matsumoto K

  Fac. Of Agriculture Graduate School Kyushu Univ.

• Osajima Y

  Kyushu Women's College

• Li Chun-hui

  Institute Of Food Biotechnology Division Of Bioresource And Bioenvironmental Sciences Graduate Schoo

• Toshiro Matsui

  Faculty Of Agriculture Graduate School Kyushu University

• Matsumoto K

  Gifu International Institute Of Biotechnology

• Maki Tetsuyoshi

  Research Laboratories Ichiban Shokuhin Co. Ltd.

• Matsumoto Kiyoshi

  Institute Of Experimental Animals Shinshu Univ.sch Of Med.

• Matsumoto K

  Central Research Laboratory Hitachi Ltd.

• Tanaka Toshiaki

  Research Center For Advanced Science And Technology The University Of Tokyo

• Tanaka Toshiaki

  Research Laboratories Ichiban Shokuhin Co. Ltd.

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