CHRONIC TOXICITY OF 2,4,6-TRI-TERT-BUTYLPHENOL IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
In order to study the chronic toxicity of 2, 4, 6-tri-tert-butylphenol (TTBP), groups of 40 Slc : Wistar rats of either sex were fed diet containing 0, 30, 100, 300 or 1000 ppm of TTBP for up to 24 months. Hematological, biochemical and histopathological examinations performed periodically revealed slight microcytic anemia, changes in some biochemical parameters relating to liver function and focal necrosis of liver cells following TTBP administration, and these changes observed in females were severer than those in males. No neoplastic responses following TTBP administration were noted. Noticeable changes were not observed in the 30 ppm group throughout the experimental period. Thus, it was concluded that TTBP causes liver injury characterized by focal necrosis with microcytic anemia and elevations of serum phospholipids and cholesterol levels presumably occurring as secondary effects following the liver injury.
- 日本トキシコロジー学会の論文
- 1991-11-25
著者
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Satoh Kanako
東京都健康安全研究センター 環境保健部
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KUROKAWA Yuji
Division of Toxicology
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Sekita Kiyoshi
Division of Toxicology, National Institute of Health Sciences
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Furuya Tsuyoshi
Division of Toxicology, National Institute of Health Sciences
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Matsumoto Kiyoshi
Institute of Experimental Animals, Shinshu University School of Medicine
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Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Kitamura Y
Division Of Pathology National Institute Of Health Sciences
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Uchida Osayuki
Division of Toxicology, Biological Safety Research Center National Institute of Health Sciences
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OCHIAI Toshiaki
Division of Toxicology, National Institute of Hygienic Sciences
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FURUYA Tsuyoshi
Biological Safety Research Center, National Institute of Health Science
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Uchida Osayuki
Division Of Toxicology National Institute Of Hygienic Sciences
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Ochiai Toshiaki
Division Of Toxicology National Institute Of Health Sciences
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Furuya Tsuyoshi
Biological Safety Research Center National Institute Of Health Science
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Matsumoto Kiyoshi
Institute Of Experimental Animals Shinshu Univ.sch Of Med.
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