CHARACTERISTICS OF PERIPHERAL BLOOD MONOCYTES AND BONE MARROW MACROPHAGES FROM RATS TREATED WITH MITOMYCIN C, 5-FLUOROURACIL OR PHENYLHYDRAZINE
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概要
- 論文の詳細を見る
We examined the cellular functional changes in bone marrow macrophages dbtained from rats treated intraperitoneally with mitomycin C (MMC), subcutandously with 5-fluorouracil (5FU) or intraperitoneally with phenylhydrazine (PHZ) for 7 days to define the mechanisms of toxicity in the bone marrow. The functions of peripheral blood monocytes and bone marrow macrophages were also compared. MMC and PHZ caused anemial and MMC and 5FU leukocytopenia. Changes in nucleated cell counts were different among the three drug-treatment groups, and MMC- and PHZ-treated bone marrow macrophages were activated for responsiveness to interleukin-1 (IL-1), and their migration activity, intracellular components and enzyme activities were increased. On the other hand, cellular functions of bone marrow macrohhages of rats treated with 5FU were suppressed.
- 日本トキシコロジー学会の論文
- 1995-02-25
著者
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Matsumoto Kiyoshi
Institute of Experimental Animals, Shinshu University School of Medicine
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Futamura Y
Mochida Pharmaceutical Co. Ltd. Shizuoka Jpn
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Futamura Yoshihiro
Department Of Cardiology Meitetsu Hospital
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Matsumoto Kiyoshi
Institute Of Experimental Animals Shinshu University School Of Medicine
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Matsumoto Kiyoshi
Institute Of Experimental Animals Shinshu Univ.sch Of Med.
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