EFFECT OF BLOOD COLLECTION IMITATING TOXICOKINETIC STUDY ON RAT HEMATOLOGICAL PARAMETERS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of blood collection imitating a one-month toxicokinetic study on hematological parameters was studied in male rats (6 weeks of age at the beginning of the experiment). Three groups were established according to blood sampling points per day; Group I (3 points), Group II (5 points) and Group III (10 points). These repeated blood samplings were carried out on the first and last days of this study, and one-point blood sampling was also done every week during the experiment. In each sampling, 0.3ml of blood was collected from the jugular vein. There were no changes in Group I , but in other groups, especially in Group III, red blood cell counts, hematocrit and hemoglobin concentration decreased during repeated blood sampling. On the other hand, white blood cell counts also decreased, but recovered within 24 hr. Platelet counts did not show any decrement. From the present result, less than 0.9 ml of blood per day is conceivable as the volume without causing changes in hematological parameters. The baseline of the sampling volume can become one reference for toxicokinetic and toxicological studies.
- 日本トキシコロジー学会の論文
- 1997-08-10
著者
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Matsumoto Kiyoshi
Institute of Experimental Animals, Shinshu University School of Medicine
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Noguchi Noriko
中外製薬
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Noguchi Noriko
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Noguchi Noriko
Toxicol.res.labs. Chugai Pharmaceu.co. Ltd.
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Noguchi Noriko
東京大学先端科学技術研究センター
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KURATA Masaaki
Toxicology Laboratory, Chugai Pharmaceutical Co., Ltd.
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KASUGA Yoshitomo
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
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MISAWA Kaoru
Toxicology Laboratory, Chugai Pharmaceutical Co., Ltd.
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KASUGA Yoshitomo
Toxicology Laboratory, Chugai Pharmaceutical Co., Ltd.
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Misawa Kaoru
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Kurata Masaaki
ファイザー製薬中央研究所 安全性研究統括部
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Kurata Masaaki
Toxicology Laboratory Chugai Pharmaceutical Co.
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Kasuga Yoshitomo
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
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Matsumoto Kiyoshi
Institute Of Experimental Animals Shinshu Univ.sch Of Med.
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Kurata Masaaki
Drug Safety Research And Development Nagoya Laboratories Pfizer Global Research And Development Pfiz
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