Battery of Tests for Profiling Abnormalities of Vitamin K-Dependent Coagulation Factors in Drug-Toxicity Studies in Rats
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概要
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A battery of simple tests for profiling abnormalities of vitamin K-dependent coagulation factors encountered in drug-toxicity studies was verified in rats treated with warfarin (3 and 10 mg/kg, p.o). The thrombotest, or hepaplastin-test, is useful as a follow-up test after routine screening tests for coagulation abnormalities based on PT and APTT, to rule out other coagulation-factor abnormalities. Measurement of coagulation factor activities (factors II, VII, IX and X) using factor-deficient human plasmas provides direct evidence of decreased activities of vitamin K-dependent factors. Furthermore, Echis carinatus venom coagulation time, together with factor II activity, allows us to confirm the generation of PIVKA-II.
- 2005-04-01
著者
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IIDAKA Takeshi
Worldwide Safety Sciences, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Japan
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Iidaka Takeshi
ファイザー 中央研究所
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Iidaka Takeshi
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
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Iidaka Takeshi
ファイザー製薬中央研究所 安全性研究統括部
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Iidaka Takeshi
Drug Safety Research And Development Nagoya Laboratories Pfizer Global Research And Development Pfiz
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Iidaka Takeshi
ファイザー製薬中央研究所 安全性研究
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Iidaka Takeshi
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
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HAMADA Yoshimasa
Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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Kurata Masaaki
ファイザー製薬中央研究所 安全性研究統括部
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Kurata Masaaki
Worldwide Safety Sciences Pfizer Global Research And Development Nagoya Laboratories Pfizer Inc.
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YAMASAKI Naoko
Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Inc.
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SASAYAMA Yukiko
Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Inc.
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Yamasaki Naoko
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
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Sasayama Yukiko
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
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Hamada Y.
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
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Hamada Yoshimasa
Worldwide Safety Sciences Global Research & Development Nagoya Laboratories Pfizer Japan Inc.
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Hamada Yoshimasa
Worldwide Safety Sciences Global Research & Development Nagoya Laboratories Pfizer Inc.
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Kurata Masaaki
Drug Safety Research And Development Nagoya Laboratories Pfizer Global Research And Development Pfiz
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