Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 2005-10-31
著者
-
IIDAKA Takeshi
Worldwide Safety Sciences, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Japan
-
HORII Ikuo
Worldwide Safety Sciences, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Japan
-
Iidaka Takeshi
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
Fujikawa Masaaki
worldwide safety sciences
-
Yamada Hiroshi
worldwide safety sciences
-
Shirai Maki
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
Shirai Maki
Worldwide Safety Sciences Global Research & Development Nagoya Laboratories Pfizer Inc.
-
Horii Ikuo
Showa Univ. (department Of Biochemical Toxicology School Of Pharmaceutical Sciences)
-
Horii I
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
-
Horii Ikuo
Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
-
Sato Yasushi
Worldwide Safety Sciences, PGRD Nagoya Laboratories, Pfizer Inc.
-
Yamada Hiroshi
Drug Safety Research & Development Pfizer Global Research & Development Nagoya Laboratories
-
Horii Ikuo
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
Fujikawa Masaaki
Drug Safety Research & Development Pfizer Global Research & Development Nagoya Laboratories
-
Fujikawa Masaaki
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Japan
-
Horii Ikuo
Worldwide Safety Sciences
-
Horii Ikuo
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
-
Hamada Y.
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
-
Fujikawa Masaaki
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Japan
-
Horii Ikuo
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Sato Yasushi
Drug Safety Research & Development Pfizer Global Research & Development Nagoya Laboratories
-
Yamada Hiroshi
Worldwide Safety Sciences Pfizer Global Research And Development Nagoya Laboratories Pfizer Japan In
-
Fujikawa Masaaki
World Wide Safety Sciences
関連論文
- P6-38 Relationship between hepatic enzyme induction and carcinogenicity in the p53 deficient mice treated with aminophenylnorharman(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
- Toxic effect onset and evaluations of medicinal drugs : horizon for Darwinian Toxicological thought
- EFFECT OF DOSE REGIMEN ON THE TOXICITY OF 2'-DEOXY-2'-METHYLIDENECYTIDINE (DMDC) IN MONKEYS
- RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS
- 21D-04-5 Effect on male reproductive organs and lymph nodes in dogs treated for long period with L-dopa and decarboxylase inhibitor.
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative : Species differences and improvement of intestinal toxicity
- 108 TOXICOLOGICAL EFFECT OF COMBINATION TREATMENT WITH INTERFERON alpha A/D AND 5'-DEOXY-5 FLUOROURIDIN (5'-DFUR) IN HCT116 AND WIDIR-BEARING AND TUMOR-FREE NUDE MICE
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative) : Toxicokinetics in monkeys, rats and mice
- CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE : REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- GENOMIC CLUSTER AND NETWORK ANALYSIS FOR PREDICTIVE SCREENING FOR HEPATOTOXICITY
- PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effect of aging on QT interval in guinea pigs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- P8-45 Estimation of exposure in toxicology study in discovery stage(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-34 Usefulness of beam walking test for prediction of adverse effects, "vertigo and dizziness"(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- In Vitro Method Investigation for Drugs Induced Vasculitis Evaluation (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Markers for detecting myocardial damage in rats : From a view of clinical pathology(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- Evaluation of the effects of Sulfasalazine, a male reproductive toxicant, on acrosome reaction in rat sperm.(GENERAL SESSION BY POSTER PRESENTATION)(DEVELOPMENT AND REPRODUCTION)
- P7-24 Investigation of the hepato-toxicity screening system in primary cell culture(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-46 Effect of reproductive toxicants on the protein expression in the rat testis(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-45 Effect of reproductive toxicants on the gene expression in the testes of rats(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Effects of sulfasalazine on gene expressions in testis and epididymis (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Method for RNA Extraction from Formalin-Fixed, Paraffin-Embedded Tissues(Test methods, Proceedings of the 32nd Annual Meeting)
- SIMULTANEOUS MEASUREMENT OF NUCLEATED CELL COUNTS AND CELLULAR DIFFERENTIALS IN RAT BONE MARROW EXAMINATION USING FLOW CYTOMETER
- P7-45 Usefulness of fecal occult blood kits by the immunity method : Examination in rats and dogs(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MECHANISM FOR SHORTENING PT AND APTT IN DOGS AND RATS : EFFECT OF FIBRINOGEN ON PT AND APTT
- Measurements for rat and canine D-dimer in plasma using human clinical latex agglutination reagents (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Mechanism for shortened PT and APTT in dogs and rats-Effect of fibrinogen on PT and APTT- (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P7-61 Variation of neurotransmitter contents in the cerebrospinal fluid of conscious dogs(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-58 Comparison of the chemicals on open-field activities in rats(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Evaluation of QT interval with telemetry system in conscious guinea pigs (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Recovery of cardiovascular parameters in beagle dogs after excitement induced by human contact(Circulatory system, Proceedings of the 32nd Annual Meeting)
- P8-22 Effect of autonomic nervous activity on QT interval in dogs(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-4 Sperm Viability and Counts by Flow Cytometric Analysis in Maturing Stage of Rats.(Proceedings of the 27th Annual Meeting)
- FLOW CYTOMETRIC ANALYSIS FOR SPERM VIABILITY AND COUNTS IN RATS TREATED WITH TRIMETHYLPHOSPHATE OR PYRIDOXINE
- 2A-03 Flow cytometric analysis for sperm viability and counts in rats treated with Trimethylphosphate or Pyridoxine
- Flow cytometric analysis of sperm viability and number in the rats treated with Trimethylphosphate and Ornidazole.
- Toxicomarker Discovery for Hepatotoxicity using Proteome Analysis Technology (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Usefulness of Teflon sonde for oral administration in rats (TEST METHODS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- MALE FERTILITY IN RATS TREATED WITH ETRETINATE FOR 4 WEEKS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- Battery of Tests for Profiling Abnormalities of Vitamin K-Dependent Coagulation Factors in Drug-Toxicity Studies in Rats
- BLOOD COAGULATION TESTS IN TOXICOLOGICAL STUDIES : REVIEW OF METHODS AND THEIR SIGNIFICANCE FOR DRUG SAFETY ASSESSMENT
- P8-42 Technical examination for repeated blood collection and hematological tests in mice(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-41 Simple methods for evaluating abnormality in vitamin K-dependent coagulation factors in rats(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- EFFECT OF ETRETINATE (AROMATIC RETINOID) TREATMENT DURING GESTATION AND LACTATION PERIODS ON VIABILITY AND SOMATIC GROWTH IN F1 RATS
- Effect of Etretinate(Aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in Fl rats
- EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
- 222 EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON FEMALE REPRODUCTIVE SYSTEM
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- P8-47 Investigation of environmental influences on the behavioral observation of rats(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P-80 Comparative 4 AND 2 Weeka Oral Repeated Dosing Studies On Male Reproductive Organs in Rats Treated With 5-Fluorouracil.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 18)COMPARATIVE 4 AND 2 WEEKS ORAL REPEATED DOSING STUDIES ON MALE REPRODUCTIVE ORGANS IN RATS TREATED WITH 5-FLUOROURACIL
- 22A-10-1 Endocrinological assessment of male reproductive toxicity in rats induced by 5-FU treatment.
- Studies on AC Electroluminescence Device Made of BaTiO_3-CaTiO_3:Pr^ Diphase Ceramics
- Enhancement of Photoluminescence in CaTiO_3:Pr^ by Ba and Sr Substitution for Ca
- Synthesis and Electric Property of CeAlO_3 Ceramics
- Correlation among Clinicopathological Parameters of Myocardial Damage in Rats Treated with Isoproterenol
- P6-20 Usefulness of measuring QT interval with chest lead in Beagle Dogs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-33 Validation of an in vitro screening assay for phospholipidosis in drug development(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- The use of gene expression profiling in rat hepatocyte cultures using adapter-tagged competitive PCR (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion
- Development and Significance of New Defined Biomarkers (SYMPOSIUM2: CURRENT STATUS AND FUTURE ASPECTS OF TOXICOLOGICALLY RESPONSIBLE BIOMARKERS) (Proceedings of the 30th Annual Meeting)
- 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta