EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Parenteral application of the active metabolite of vitamin D_3, 1,25-dihydroxyvitamin D_3, has been anticipated to have remarkable efficacy in secondary hyperparathyroidism. However, in a reproduction seg. I study in rats, poor reproductive performance was reflected in a decrease in the number of matings, implantations and live births. These changes were though reversible after treatment with the compound was discontinued. In order to clarify the mechanism of these reversible toxicities, the following were examined in female rats treated with the D_3 metabolite: 1. effect on the estrous cycle (no treatment for 2 weeks, treatment for 3 weeks and recovery for 2 weeks), and 2. effect on the maintenance of pregnancy (treatment for 2 weeks before mating and during the gestation period). In both groups, the levels of calcium, calcitonin, PTH and progesterone in serum were measured, and histopathological examination of the thyroid, parathyroid, ovary and uterus was carried out. The following results were observed: 1) disturbance of the estrous cycle, 2) hypofunctional changes in the corpus luteum in the ovary, and the epithelium, endometrium and uterine gland in the uterus with a decrease in the serum progesterone level and 3) hypercalcemia with a decrease in calcitonin or PTH levels in serum with morphological changes including atrophy and cyst-formation in the parathyroid. However, the above changes were reversible, and recovery was observed after administration of the compound was discontinued. These results indicate that the hypercalcemia caused by 1,25-dihydroxyvitamin D_3 disrupts endocrinological homeostasis which in turn temporarily disrupts the female reproductive system. Furthermore, it was suggested that 1,25-dihydroxyvitamin D_3 itself directly influences on endocrinological organs (hypothalamus, pituitary, parathyroid and thyroid) and reproductive organs (ovary and uterus).
- 日本トキシコロジー学会の論文
- 1992-08-25
著者
-
Horii Ikuo
Department of Toxicology and Pathology, Nippon Roche K.K.Research Center
-
Horii Ikuo
Department Of Preclinical Science Nippon Roche K. K. Research Center
-
Horii Ikuo
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
FUJII Toshiyuki
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
TAKIZAWA Setsuko
Dept. of Preclinical Science, Nippon Roche Research Center
-
TAKIZAWA Setsuko
Department of Toxicology and Pathology, Nippon Roche Research Center
-
Fujii T
Teikyo Univ. Tokyo Jpn
-
FUJII Tomoko
Department of Pharmacology, Teikyo University, School of Medicine
-
Takizawa Setsuko
日本ロシュ研究所
-
Takizawa Setsuko
Dept. Of Preclinical Science Nippon Roche Research Center
-
Takizawa Setsuko
Department Of Preclinical Science Nippon Roche K. K. Research Center
-
Fujii Tomoko
Department Of Biology School Of Education Waseda University
-
Takizawa Setsuko
日本ロシュ
-
Horii Ikuo
Department Of Biochemical Toxicology School Of Pharmacy Showa University
関連論文
- Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
- EFFECT OF DOSE REGIMEN ON THE TOXICITY OF 2'-DEOXY-2'-METHYLIDENECYTIDINE (DMDC) IN MONKEYS
- RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS
- 21D-04-5 Effect on male reproductive organs and lymph nodes in dogs treated for long period with L-dopa and decarboxylase inhibitor.
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative : Species differences and improvement of intestinal toxicity
- 108 TOXICOLOGICAL EFFECT OF COMBINATION TREATMENT WITH INTERFERON alpha A/D AND 5'-DEOXY-5 FLUOROURIDIN (5'-DFUR) IN HCT116 AND WIDIR-BEARING AND TUMOR-FREE NUDE MICE
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative) : Toxicokinetics in monkeys, rats and mice
- CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE : REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- GENOMIC CLUSTER AND NETWORK ANALYSIS FOR PREDICTIVE SCREENING FOR HEPATOTOXICITY
- PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effect of aging on QT interval in guinea pigs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- P8-45 Estimation of exposure in toxicology study in discovery stage(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-34 Usefulness of beam walking test for prediction of adverse effects, "vertigo and dizziness"(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- In Vitro Method Investigation for Drugs Induced Vasculitis Evaluation (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- P7-24 Investigation of the hepato-toxicity screening system in primary cell culture(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-46 Effect of reproductive toxicants on the protein expression in the rat testis(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-45 Effect of reproductive toxicants on the gene expression in the testes of rats(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Effects of sulfasalazine on gene expressions in testis and epididymis (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- SIMULTANEOUS MEASUREMENT OF NUCLEATED CELL COUNTS AND CELLULAR DIFFERENTIALS IN RAT BONE MARROW EXAMINATION USING FLOW CYTOMETER
- P7-45 Usefulness of fecal occult blood kits by the immunity method : Examination in rats and dogs(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MECHANISM FOR SHORTENING PT AND APTT IN DOGS AND RATS : EFFECT OF FIBRINOGEN ON PT AND APTT
- Measurements for rat and canine D-dimer in plasma using human clinical latex agglutination reagents (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Mechanism for shortened PT and APTT in dogs and rats-Effect of fibrinogen on PT and APTT- (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P7-61 Variation of neurotransmitter contents in the cerebrospinal fluid of conscious dogs(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-58 Comparison of the chemicals on open-field activities in rats(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Evaluation of QT interval with telemetry system in conscious guinea pigs (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A Case : Anemia in animal and human studies
- O-4 Sperm Viability and Counts by Flow Cytometric Analysis in Maturing Stage of Rats.(Proceedings of the 27th Annual Meeting)
- FLOW CYTOMETRIC ANALYSIS FOR SPERM VIABILITY AND COUNTS IN RATS TREATED WITH TRIMETHYLPHOSPHATE OR PYRIDOXINE
- 2A-03 Flow cytometric analysis for sperm viability and counts in rats treated with Trimethylphosphate or Pyridoxine
- Flow cytometric analysis of sperm viability and number in the rats treated with Trimethylphosphate and Ornidazole.
- CHALLENGE TO IN VITRO ANTIGENICITY STUDY IN HUMAN LYMPHOCYTES : ESTABLISHMENT OF TEST SYSTEM USING HETEROGENEOUS PROTEINS AS ANTIGENS
- Serum concentrations of Growth Hormone and Prolactin in Male and Female Rats : Influence of Aging and Pituitary Lesions
- Toxicomarker Discovery for Hepatotoxicity using Proteome Analysis Technology (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Usefulness of Teflon sonde for oral administration in rats (TEST METHODS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- MALE FERTILITY IN RATS TREATED WITH ETRETINATE FOR 4 WEEKS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- TOXICOLOGICAL CORRELATION BETWEEN CHANGES IN BLOOD BIOCHEMICAL PARAMETERS AND LIVER HISTOPATHOLOGICAL FINDINGS
- EFFECT OF ETRETINATE (AROMATIC RETINOID) TREATMENT DURING GESTATION AND LACTATION PERIODS ON VIABILITY AND SOMATIC GROWTH IN F1 RATS
- Effect of Etretinate(Aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in Fl rats
- EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
- 222 EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON FEMALE REPRODUCTIVE SYSTEM
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- "A-12 Investigation of SCID mice transferred with human lymphocytes (hu-PBL-SCID mice) for the evaluation of toxicity on human immune system. : Human immunoglobulin production in hu-PBL-SCID mice
- P-80 Comparative 4 AND 2 Weeka Oral Repeated Dosing Studies On Male Reproductive Organs in Rats Treated With 5-Fluorouracil.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 18)COMPARATIVE 4 AND 2 WEEKS ORAL REPEATED DOSING STUDIES ON MALE REPRODUCTIVE ORGANS IN RATS TREATED WITH 5-FLUOROURACIL
- 22A-10-1 Endocrinological assessment of male reproductive toxicity in rats induced by 5-FU treatment.
- COMPARATIVE TOXICOLOGICAL ASSESSMENT OF A WATER-SOLUBLE AZOLE ADMINISTERED BOTH ORALLY AND BY INTRAVENOUS CONTINUOUS INFUSION IN CYNOMOLGUS MONKEYS
- TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
- Ovarian Carbonyl Reductase Delayed Onset of Persistent Estrus in the Offspring of Parathyroidectomized Mother Rats
- A case of eosinophilic orbital myositis associated with CSS
- SEX DIFFERENCE IN THE DEVELOPMENT OF HYPERSENSITIVITY OR TOLERANCE TO HALOPERIDOL IN THE RAT
- Organ Specificity in Growth Stimulating Action of Exogeneous RNA in Male Accessory Sex Organs of Rats.
- EFFECTS OF DOXIFLURIDINE(DFUR)ON MOUSE THYMOCYTE DIFFERENTIATION
- EFFECTS OF HYDROCHLORIC ACID ON THE DEVELOPMENT OF ENTEROCHROMAFFIN-LIKE (ECL) CELL HYPERPLASIA IN THE RAT STOMACH INDUCED BY OMEPRAZOLE
- Time Course of the Negative Feedback Effect of Testosterone on Serum Gonadotropiiis in Prepubertal Male Rats
- Report 3 : FUTURE PROSPECTS FOR TOXICOKINETICS : ITS ABILITY TO PREDICT DRUG ADVERSE EVENTS IN HUMANS (TOXICOKINETICS)
- COMPARATIVE IMMUNOTOXICITY ASSESSMENT OF N^4-TRIMETHOXYBENZOYL-5'-DEOXY-5-FLUOROCYTIDINE (RO 09-1390) AND 5'-DEOXY-5-FLUOROURIDINE (5'-DFUR) IN BDF1 MICE
- P8-33 Validation of an in vitro screening assay for phospholipidosis in drug development(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- The use of gene expression profiling in rat hepatocyte cultures using adapter-tagged competitive PCR (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Chromogranin A-Like Proteins in the Heat-Stable Fraction of Sea Urchin Eggs, Embryos and the Substances Secreted with Sperm(Developmental Biology)
- Insulin - Induced Hypoglycemia Stimulates Both Adrenaline and Noradrenaline Release from Adrenal Medulla in 21 - Day - Old Rats
- Increased Responsiveness to Synthetic Thyrotropin-Releasing Hormone (TRH) in Androgenized Adult Rats with Special Reference to the Dose of Testosterone Propionate for Androgenization
- Age Difference in the Response to Synthetic Luteinizing Hormone-Releasing Hormone (LHRH) in Androgenized Rats with Special Reference to the Dose of Testosterone Propionate for Androgenization
- Prolactin Release by Synthetic Luteinizing Hormone-Releasing Hormone (LHRH) in Thyroidectomized-Androgenized. Adult Rats
- DECREASE IN THE LETHAL EFFECT OF ISOPROTERENOL IN CHRONIC HYPOCALCEMIC STATE BUT NOT IN ACUTE HYPOCALCEMIC STATE PRODUCED BY PARATHYROIDECTOMY IN RATS
- Increased Mortality of Kainic Acid by Pretreatment with Nicardipine, a Calcium Channel Blocker in Rats
- Age Difference in the Prostate Hypertrophy Induced by the Removal of the Seminal Vesicle in Rats
- Sex Difference in Adaptation of Serum Calcium Level to the Gradual Deprivation of Parathyroid Hormone and to the Following Thyroidectomy
- Reappearance of Cyclicity of Vaginal Smears in Androgen-Sterilized Rats following Thyroidectomy
- PRESSOR ACTION OF LUTEINIZING HORMONE-RELEASING HORMONE IN THE RAT
- Hypoglycemia-induced Catecholamine Release from Adrenals in 21-day-old Rats is Blocked by Hexamethonium Pretreatment(Endocrinology)
- A NEW DIRECTION OF DRUG TOXICITY RESEARCH:DELAYED ADVERSE EFFECTS OF DRUGS
- S1-5 FUNCTIONAL TOXICITY ON THE OFFSPRING AFTER MATERNAL EXPOSURE TO DRUGS.
- THE BENZODIAZEPINE RECEPTOR AND RECEPTOR TOLERANCE PRODUCED BY CHRONIC TREATMENT OF DIAZEPAM
- ELEVATION OF THE MAXIMAL SEIZURE THRESHOLD PRODUCED BY CALCIUM HYDROXIDE IN RATS
- ALTERATION IN THE RESPONSE TO KAINIC ACID IN RATS EXPOSED TO GLUFOSINATE AMMONIUM DURING INFANTILE PERIOD OR FETAL LIFE
- 2B-22 Homologous passive cutaneous anaphylaxis test in mice
- Inhibitory effect of endothelin receptor antagonist on growth of 3T3-E1 osteoblastic cells in vitro.
- AROMATIC RETINOID RO 40-8757 REDUCES IMMUNOTOXICITIES OF CYCLOPHOSPHAMIDE AS REVEALED BY IMMUNOHISTOCHEMICAL STAINING OF LYMPHOID TISSUES AND GENERAL PATHOLOGIC EXAMINATIONS
- Investigation of in vitro antigenicity study by using dendritic cells induced from mouse bone marrow cells. Expression of cell surface markers by exposure to antigens.(GENERAL SESSION BY ORAL PRESENTATION)(IMMUNE AND ALLERGIC SYSTEM)
- ENDOCRINOLOGICAL ASSESSMENT OF TOXIC EFFECTS ON THE MALE REPRODUCTIVE SYSTEM IN RATS TREATED WITH 5-FLUOROURACIL FOR 2 OR 4 WEEKS
- O12-14 Significant endocrinological parameters for the assessment of male reproductive toxicity induced by 1, 3-Dinitrobenzene or Taxol
- MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion
- 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta