Insulin - Induced Hypoglycemia Stimulates Both Adrenaline and Noradrenaline Release from Adrenal Medulla in 21 - Day - Old Rats
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概要
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It has been well-established that insulin-induced hypoglycemia evokes preferential adrenaline release from the adrenal medulla in fasted adult rats. The present study examined the responsiveness to hypoglycemia in fasted 21-day-old and 8-week-old rats. The recovery of adrenaline in the chromaffin granule fraction prepared from the 8-week-old rat adrenal homogenate decreased 30 min after subcutaneous injection of 3 U/kg insulin, whereas the recovery of both adrenaline and noradrenaline was diminished in 21-day-old rats. In electron microscopy, Q-shaped profiles, indicative of exocytosis, were frequently observed in adrenaline- and noradrenaline-storing cells of 21-day-old rats. These results indicate that the responsiveness of the noradrenaline-storing cells to hypoglycemia in 21-day-old rats is different from that in young adult rats.
- 社団法人 日本薬理学会の論文
- 1995-12-01
著者
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FUJII Tomoko
Department of Pharmacology, Teikyo University, School of Medicine
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Fujino Yukio
Department Of Pharmacology Teikyo University School Of Medicine
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Fujii Tomoko
Department Of Biology School Of Education Waseda University
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FUJII TOMOKO
Department of Pharmacology, Teikyo University School of Medicine
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