Suppression of hepatic HMG-CoA reductase activity by .BETA.-muricholic acid in mice fed a diet containing cholesterol and cholic acid.
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概要
- 論文の詳細を見る
A diet containing cholesterol and cholic acid (SID) is known to induce the formation of cholesterol fatty liver as well as cholesterol gallstones. The activity of HMG-CoA reductase, one of the key enzymes for cholesterol synthesis in the liver, is significantly lowered by addition of β-muricholic acid to SID. The prevention of fatty liver formation by β-muricholic acid was accompanied by the suppression of HMG-CoA reductase activity.
- 公益社団法人 日本薬理学会の論文
著者
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Nakayama Koji
Department Of Chemistry Graduate School Of Science Hiroshima University
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Fujino Yukio
Department Of Pharmacology Teikyo University School Of Medicine
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YONAGA Takara
Department of Pharmacology, Teikyo University School of Medicine
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YOSHIMURA Kuniyoshi
Department of Pharmacology, Teikyo University School of Medicine
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FURUYA Yutaka
Department of Pharmacology, Teikyo University School of Medicine
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- Suppression of hepatic HMG-CoA reductase activity by .BETA.-muricholic acid in mice fed a diet containing cholesterol and cholic acid.