2A-03 Flow cytometric analysis for sperm viability and counts in rats treated with Trimethylphosphate or Pyridoxine
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1997-10-15
著者
-
HORII Ikuo
Dept. of Preclinical Science, Nippon Roche Research Center
-
Horii I
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
-
Horii Ikuo
Dept. Of Preclinical Science Nippon Roche Research Center
-
Katoh C
Nippon Roche K. K. Kanagawa Jpn
-
Katoh Chiaki
Dept.toxicology And Pathology Nippon Roche Research Center
-
Horii Ikuo
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
TAKIZAWA Setsuko
Dept. of Preclinical Science, Nippon Roche Research Center
-
Katoh Chiaki
Dept. Of Preclinical Science Nippon Roche Research Center
-
Takizawa Setsuko
Dept. Of Preclinical Science Nippon Roche Research Center
-
Takizawa Setsuko
日本ロシュ
-
Horii Ikuo
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
関連論文
- Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
- EFFECT OF DOSE REGIMEN ON THE TOXICITY OF 2'-DEOXY-2'-METHYLIDENECYTIDINE (DMDC) IN MONKEYS
- RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS
- 21D-04-5 Effect on male reproductive organs and lymph nodes in dogs treated for long period with L-dopa and decarboxylase inhibitor.
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative : Species differences and improvement of intestinal toxicity
- 108 TOXICOLOGICAL EFFECT OF COMBINATION TREATMENT WITH INTERFERON alpha A/D AND 5'-DEOXY-5 FLUOROURIDIN (5'-DFUR) IN HCT116 AND WIDIR-BEARING AND TUMOR-FREE NUDE MICE
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative) : Toxicokinetics in monkeys, rats and mice
- CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE : REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- GENOMIC CLUSTER AND NETWORK ANALYSIS FOR PREDICTIVE SCREENING FOR HEPATOTOXICITY
- PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effect of aging on QT interval in guinea pigs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- P8-45 Estimation of exposure in toxicology study in discovery stage(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-34 Usefulness of beam walking test for prediction of adverse effects, "vertigo and dizziness"(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- In Vitro Method Investigation for Drugs Induced Vasculitis Evaluation (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- P7-24 Investigation of the hepato-toxicity screening system in primary cell culture(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-46 Effect of reproductive toxicants on the protein expression in the rat testis(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-45 Effect of reproductive toxicants on the gene expression in the testes of rats(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Effects of sulfasalazine on gene expressions in testis and epididymis (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- A10 IMMUNOTOXICOLOGICAL STUDIES OF FURTULON, 5-FU, CYCLOSPORIN A AND UBENIMEX IN RATS
- SIMULTANEOUS MEASUREMENT OF NUCLEATED CELL COUNTS AND CELLULAR DIFFERENTIALS IN RAT BONE MARROW EXAMINATION USING FLOW CYTOMETER
- P7-45 Usefulness of fecal occult blood kits by the immunity method : Examination in rats and dogs(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MECHANISM FOR SHORTENING PT AND APTT IN DOGS AND RATS : EFFECT OF FIBRINOGEN ON PT AND APTT
- Measurements for rat and canine D-dimer in plasma using human clinical latex agglutination reagents (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Mechanism for shortened PT and APTT in dogs and rats-Effect of fibrinogen on PT and APTT- (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P7-61 Variation of neurotransmitter contents in the cerebrospinal fluid of conscious dogs(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-58 Comparison of the chemicals on open-field activities in rats(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Evaluation of QT interval with telemetry system in conscious guinea pigs (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-4 Sperm Viability and Counts by Flow Cytometric Analysis in Maturing Stage of Rats.(Proceedings of the 27th Annual Meeting)
- FLOW CYTOMETRIC ANALYSIS FOR SPERM VIABILITY AND COUNTS IN RATS TREATED WITH TRIMETHYLPHOSPHATE OR PYRIDOXINE
- 2A-03 Flow cytometric analysis for sperm viability and counts in rats treated with Trimethylphosphate or Pyridoxine
- Flow cytometric analysis of sperm viability and number in the rats treated with Trimethylphosphate and Ornidazole.
- Assessment of immunization/challenging procedures in antigenicity study of pharmaceuticals in guinea pigs. : with/without protein conjugate and its dosage
- Preparation Method of Antigens in Antigenicity Studies II : Antigen preparation of Sulfanilamide (SAM)
- Preparation Method of Antigens in Antigenicity Studies I : Preparation of Penicillin G-protein conjugates
- Toxicomarker Discovery for Hepatotoxicity using Proteome Analysis Technology (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Usefulness of Teflon sonde for oral administration in rats (TEST METHODS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP. 8. ANIMAL CONTROL SYSTEM
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP. 7. DATA STORAGE SYSTEM
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP : RANDOM SAMPLING SYSTEM
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP : QAU SYSTEM
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP. 3. ACUTE TOXICITY STUDY
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP. 2. REPRODUCTION SEG. I, II AND III STUDIES
- LABO-AUTOMATION AND ITS REGULATION IN TOXICOLOGICAL STUDIES IN COMPLIANCE WITH GLP. 1. LONG TERM TOXICITY STUDY
- MALE FERTILITY IN RATS TREATED WITH ETRETINATE FOR 4 WEEKS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- EFFECT OF ETRETINATE (AROMATIC RETINOID) TREATMENT DURING GESTATION AND LACTATION PERIODS ON VIABILITY AND SOMATIC GROWTH IN F1 RATS
- Effect of Etretinate(Aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in Fl rats
- EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
- 222 EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON FEMALE REPRODUCTIVE SYSTEM
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- Cross-reactivity of carrier proteins in antigenicity study in guinea pigs.
- P-80 Comparative 4 AND 2 Weeka Oral Repeated Dosing Studies On Male Reproductive Organs in Rats Treated With 5-Fluorouracil.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 18)COMPARATIVE 4 AND 2 WEEKS ORAL REPEATED DOSING STUDIES ON MALE REPRODUCTIVE ORGANS IN RATS TREATED WITH 5-FLUOROURACIL
- 22A-10-1 Endocrinological assessment of male reproductive toxicity in rats induced by 5-FU treatment.
- Protective Effects of Arotinoid on Cyclophosphamide(CPM) Toxicities on Immune System
- 22D-09-5 In Vitro Toxicological Evaluation by Using Fetal Rat Primary Lung Cells.
- 2B-10 Morphometric evaluation method b using the co-culture system of rat primary hepatocytes and Candida albicans in the development of antifungal drugs.
- A12 EVALUATION AND ITS MECHANISM OF DIARRHEA INDUCTION BY FLUOROPYRIMIDINE DERIVATIVES
- P8-33 Validation of an in vitro screening assay for phospholipidosis in drug development(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- The use of gene expression profiling in rat hepatocyte cultures using adapter-tagged competitive PCR (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- O12-01 Investigation of in vitro evaluation system using fetal rat lung cell spheroids for a txicity evaluation system
- 236 IMMUNOTOXICOLOGICAL EVALUATION OF HUMAN RECOMBINANT INTERLEUKIN-2 (RIL-2) IN MICE WITH CELL SURFACE MARKER ANALYSIS
- O-57 In Vitro Effects of 6-Aminonicotinamide (6-ANA) on a Rat Brain Spheroid (SP) Long Term Culture System.(Proceedings of the 27th Annual Meeting)
- 22B-09-1 An Investigation of A Rat Brain Spheroid Culture System for the In Vitro Evaluation of Neurotoxicity.
- 220 HEPATOTOXICITY EVALUATION OF MAO (MONOMINE OXIDASE) INHIBITORY DRUGS : CYTOTOXICITY TEST USING RAT PRIMARY CULTURED HEPATOCYTES
- 23S3A-01-2 New Trends in Pharmaceutical Research from Discovery to Development : The Position of Toxicological Research in Pharmaceutical Development and its New Strategy
- O12-02 Similarity of an in vitro rat brain spheroid culture system to the in vivo brain : Differentiation of neural and glial cells and reactions to toxic compounds
- ON THE TECHNIQUES FOR THE REPEATED I.V. INJECTION IN RATS (I. Problems in drug administration techniques)
- PROCEDURE FOR THE RENAL FUNCTION TESTS IN RATS AND ITS RELATED PROBLEMS. III. PSP EXCRETION TEST AND CREATININE CLEARANCE TEST IN CHRONIC NEPHROTOXICITY
- MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion
- 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
- STORAGE SYSTEM FOR THE HISTOPATHOLOGY SPECIMENS AND ITS MANAGEMENT (III. Histopathologic diagnosis in toxicity study)