6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
スポンサーリンク
概要
- 論文の詳細を見る
- 2012-06-01
著者
-
Horii Ikuo
Showa Univ. (department Of Biochemical Toxicology School Of Pharmaceutical Sciences)
-
Horii I
Drug Safety Research And Development Pfizer Global Research And Development Nagoya Laboratories. Pfi
-
Horii Ikuo
Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
-
Horii Ikuo
Department Of Preclinical Science Nippon Roche K. K. Research Center
-
Yoshida Tomoko
Department Of Nuclear Engineering Nagoya University
-
Yoshida Takemi
Dept.biochem.toxicol. Showa Univ.
-
Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
-
Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
-
Yoshida Teiji
Department Of Physics Faculty Of Science Tohoku University
-
Fukushima Tamio
Drug Safety Research And Development Nagoya Laboratories Pfizer Japan Inc.
-
Fukushima Tamio
Pfizer Global Research & Development Toxicology Nagoya Laboratoreis
-
Horii Ikuo
Worldwide Safety Sciences Pgrd Nagoya Laboratories Pfizer Inc.
-
Yoshida Takahiko
Department Of Environmental Health Division Of Community And Environmental Health Tokai University S
-
Yoshida Takemi
School Of Pharmaceutical Sciences Showa University
-
Horii Ikuo
Worldwide Safety Sciences Pfizer Global Research & Development Nagoya Laboratories Pfizer Inc.
-
TAKI KENJI
Departments of Emergency Medicine
-
Yoshida Takemi
Pfizer Japan Inc. Drug Safety R&d Pfizer Global R&d
-
Horii Ikuo
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Fukushima Tamio
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Taki Kenji
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Ise Ryota
Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Ise Ryota
Department Of Biochemical Toxicology School Of Pharmacy Showa University
-
FUKUSHIMA Tamio
Department of Biochemical Toxicology, School of Pharmacy Showa University
-
Horii Ikuo
Department Of Biochemical Toxicology School Of Pharmacy Showa University
-
Fukushima Tamio
Department Of Biochemical Toxicology School Of Pharmacy Showa University
-
Taki Kenji
Department Of Biochemical Toxicology School Of Pharmacy Showa University
-
Yoshida Tomoko
Department of Biochemical Toxicology, School of Pharmacy Showa University
関連論文
- Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages
- Development of in vitro 3T3 Cell Neutral Red Uptake Phototoxicity Screening System(Test methods, Proceedings of the 32nd Annual Meeting)
- Toxic effect onset and evaluations of medicinal drugs : horizon for Darwinian Toxicological thought
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- EFFECT OF DOSE REGIMEN ON THE TOXICITY OF 2'-DEOXY-2'-METHYLIDENECYTIDINE (DMDC) IN MONKEYS
- RELATIONSHIP BETWEEN AUC of 5'-DFUR AND TOXICITY OF CAPECITABINE, FLUOROPYRIMIDINE CARBAMATE ANALOGS, AND 5'-DFUR IN MONKEYS, MICE, AND RATS
- 21D-04-5 Effect on male reproductive organs and lymph nodes in dogs treated for long period with L-dopa and decarboxylase inhibitor.
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative : Species differences and improvement of intestinal toxicity
- 108 TOXICOLOGICAL EFFECT OF COMBINATION TREATMENT WITH INTERFERON alpha A/D AND 5'-DEOXY-5 FLUOROURIDIN (5'-DFUR) IN HCT116 AND WIDIR-BEARING AND TUMOR-FREE NUDE MICE
- Toxicological assessment of a novel anti-tumor agent Capecitabine (Ro 09-1978, 5'-DFCR derivative) : Toxicokinetics in monkeys, rats and mice
- CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE : REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- GENOMIC CLUSTER AND NETWORK ANALYSIS FOR PREDICTIVE SCREENING FOR HEPATOTOXICITY
- PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics X(Test methods, Proceedings of the 32nd Annual Meeting)
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effect of aging on QT interval in guinea pigs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- P8-45 Estimation of exposure in toxicology study in discovery stage(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P8-34 Usefulness of beam walking test for prediction of adverse effects, "vertigo and dizziness"(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Magnetization Measurement of NENP and NINO in High Magnetic Field
- Guinea Pig Maximization Test of Tri-ethylene Glycol Mono-methacrylate
- The Efficacy of the Dentin Adhesive to the Caries-affected Dentin
- Detection of Bisphenol-A in Dental Materials by Gas Chromatography-Mass Spectrometry
- Effect of 10% Phosphoric acid Conditioning on the Efficacy of a Dentin Bonding System
- Effectiveness of Simplified Dentin Bonding Systems
- In Vitro Method Investigation for Drugs Induced Vasculitis Evaluation (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Intermediate Valence State of La_Eu_Ni_2(Si_Ge_x)_2 Compounds (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Angle-Resolved Photoemission Spectroscopy of (Ca,Na)_2CuO_2Cl_2 Crystals: Fingerprints of a Magnetic Insulator in a Heavily Underdoped Superconductor (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Angle-Resolved Photoemission Spectroscopy of (Ca, Na)_2CuO_2Cl_2 Crystals : Fingerprints of a Magnetic Insulator in a Heavily Underdoped Superconductor
- ^Al Nuclear Magnetic Relaxation Studies of Spin Fluctuation in Ual_2
- ^P Nuclear Magnetic Relaxation Studies of the Dynamical Magnetic Behavior of UP
- P7-24 Investigation of the hepato-toxicity screening system in primary cell culture(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-46 Effect of reproductive toxicants on the protein expression in the rat testis(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-45 Effect of reproductive toxicants on the gene expression in the testes of rats(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Effects of sulfasalazine on gene expressions in testis and epididymis (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- SIMULTANEOUS MEASUREMENT OF NUCLEATED CELL COUNTS AND CELLULAR DIFFERENTIALS IN RAT BONE MARROW EXAMINATION USING FLOW CYTOMETER
- P7-45 Usefulness of fecal occult blood kits by the immunity method : Examination in rats and dogs(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MECHANISM FOR SHORTENING PT AND APTT IN DOGS AND RATS : EFFECT OF FIBRINOGEN ON PT AND APTT
- Measurements for rat and canine D-dimer in plasma using human clinical latex agglutination reagents (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Mechanism for shortened PT and APTT in dogs and rats-Effect of fibrinogen on PT and APTT- (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P7-61 Variation of neurotransmitter contents in the cerebrospinal fluid of conscious dogs(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-58 Comparison of the chemicals on open-field activities in rats(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Evaluation of QT interval with telemetry system in conscious guinea pigs (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- FLOW CYTOMETRIC ANALYSIS FOR SPERM VIABILITY AND COUNTS IN RATS TREATED WITH TRIMETHYLPHOSPHATE OR PYRIDOXINE
- 2A-03 Flow cytometric analysis for sperm viability and counts in rats treated with Trimethylphosphate or Pyridoxine
- Flow cytometric analysis of sperm viability and number in the rats treated with Trimethylphosphate and Ornidazole.
- CHALLENGE TO IN VITRO ANTIGENICITY STUDY IN HUMAN LYMPHOCYTES : ESTABLISHMENT OF TEST SYSTEM USING HETEROGENEOUS PROTEINS AS ANTIGENS
- TISSUE- AND DOSE-DEPENDENT ALTERATION OF STRESS-INDUCIBLE PROTEINS BY β_2-ADRENOCEPTOR AGONIST, SALBUTAMOL, IN RATS
- QUANTITATIVE ESTIMATION OF MYOCARDIAL FIBROSIS BASED ON RECEPTOR OCCUPANCY FOR β_2-ADRENERGIC RECEPTOR AGONISTS IN RATS
- Establishment and Peculiarity of Ouabain-resistant THP-1 cells
- INITIAL METABOLISM OF GAMMA-HEXACHLOROCYCLOHEXANE (γ-HCH) BY RAT LIVER MICROSONES
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- P12-08 Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-metabolizing Enzymes In Vivo and In Vitro
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- Toxicomarker Discovery for Hepatotoxicity using Proteome Analysis Technology (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Usefulness of Teflon sonde for oral administration in rats (TEST METHODS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- MALE FERTILITY IN RATS TREATED WITH ETRETINATE FOR 4 WEEKS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- Birefringence Induced by Lattice Imperfections in the Paraelectric Phase of KH_2PO_4
- Orientations of the Optical Indicatrices of KH_2PO_4 and NH_4H_2PO_4 in Their Low Temperature Phases
- EFFECT OF ETRETINATE (AROMATIC RETINOID) TREATMENT DURING GESTATION AND LACTATION PERIODS ON VIABILITY AND SOMATIC GROWTH IN F1 RATS
- Effect of Etretinate(Aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in Fl rats
- EFFECT OF 1,25-DIHYDROXYVITAMIN D_3 ON THE FEMALE REPRODUCTIVE SYSTEM IN RATS
- Bisphenol-A contents in materials used in pediatric dentistry
- Regulation of ERK-Mediated Signal Transduction by p38 MAP Kinase in Human Monocytic THP-1 Cells
- INDUCTION OF HEPATIC CYP2B1/2 BY A TERATOGENIC COMPOUND cis-1-[-4-P-MENTHANE-8-YLOXY)PHENYL]PIPERADINE(YM9429)IN RATS
- Mechanism of Heme Oxygenase-1 (HO-1) Induction by a Glutathione Depletor, Phorone in Rar Livers
- Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
- "A-12 Investigation of SCID mice transferred with human lymphocytes (hu-PBL-SCID mice) for the evaluation of toxicity on human immune system. : Human immunoglobulin production in hu-PBL-SCID mice
- P-80 Comparative 4 AND 2 Weeka Oral Repeated Dosing Studies On Male Reproductive Organs in Rats Treated With 5-Fluorouracil.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 18)COMPARATIVE 4 AND 2 WEEKS ORAL REPEATED DOSING STUDIES ON MALE REPRODUCTIVE ORGANS IN RATS TREATED WITH 5-FLUOROURACIL
- COMPARATIVE TOXICOLOGICAL ASSESSMENT OF A WATER-SOLUBLE AZOLE ADMINISTERED BOTH ORALLY AND BY INTRAVENOUS CONTINUOUS INFUSION IN CYNOMOLGUS MONKEYS
- TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
- EFFECTS OF DOXIFLURIDINE(DFUR)ON MOUSE THYMOCYTE DIFFERENTIATION
- Report 3 : FUTURE PROSPECTS FOR TOXICOKINETICS : ITS ABILITY TO PREDICT DRUG ADVERSE EVENTS IN HUMANS (TOXICOKINETICS)
- COMPARATIVE IMMUNOTOXICITY ASSESSMENT OF N^4-TRIMETHOXYBENZOYL-5'-DEOXY-5-FLUOROCYTIDINE (RO 09-1390) AND 5'-DEOXY-5-FLUOROURIDINE (5'-DFUR) IN BDF1 MICE
- P8-33 Validation of an in vitro screening assay for phospholipidosis in drug development(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- The use of gene expression profiling in rat hepatocyte cultures using adapter-tagged competitive PCR (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 2B-22 Homologous passive cutaneous anaphylaxis test in mice
- Inhibitory effect of endothelin receptor antagonist on growth of 3T3-E1 osteoblastic cells in vitro.
- AROMATIC RETINOID RO 40-8757 REDUCES IMMUNOTOXICITIES OF CYCLOPHOSPHAMIDE AS REVEALED BY IMMUNOHISTOCHEMICAL STAINING OF LYMPHOID TISSUES AND GENERAL PATHOLOGIC EXAMINATIONS
- Investigation of in vitro antigenicity study by using dendritic cells induced from mouse bone marrow cells. Expression of cell surface markers by exposure to antigens.(GENERAL SESSION BY ORAL PRESENTATION)(IMMUNE AND ALLERGIC SYSTEM)
- ENDOCRINOLOGICAL ASSESSMENT OF TOXIC EFFECTS ON THE MALE REPRODUCTIVE SYSTEM IN RATS TREATED WITH 5-FLUOROURACIL FOR 2 OR 4 WEEKS
- O12-14 Significant endocrinological parameters for the assessment of male reproductive toxicity induced by 1, 3-Dinitrobenzene or Taxol
- MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion
- 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta