STUDIES ON THYROID FUNCTION IN RATS SUBJECTED TO REPEATED ORAL ADMINISTRATION WITH KOJIC ACID

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概要

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• To elucidate the effects of kojic acid on thyroid function, the compound was given orally to male rats for 4 weeks at 0, 4, 15, 62.5, 250 and 1,000 mg/kg. In 1,000 mg/kg treatment of kojic acid, the rats showed a slight decrease in motility, inhibition of body weight gain, and a decrease in food consumption. An increase in thyroid weight and a morphological change, i.e., hypertrophy of epithelial cells of the thyroid gland follicles, were observed after 1 week of administration. In addition, the uptake of radioactive iodine from blood into the thyroid gland was enhanced and the TCA-precipitable radioactive iodine in the thyroid gland increased in those rats. However, the rates of the iodination in the thyroid gland did not change during the experiment period. Although serum T4 concentration was low in the rats treated with 1,000 mg/kg kojic acid, it was not observed in any changes in TSH concentration. None of these changes were found in the other groups. These observations suggest that massive administration of kojic acid may decrease blood T4 concentration and that thyroid function may be enhanced compensatorily. On the other hand, the absorption of kojic acid was rapid as manifested by the T_<max> of blood concentrations of radioactivity, which was as short as 1.0±0.0 hr, and the t_<1/2> was 4.8±0.3 hr. Blood concentrations of radioactivity disappeared nearly completely at 24 hr after administration. This result indicates that the toxic effect observed on the thyroid gland treated with only the largest dosage of kojic acid may depend on a fast decrease following a transient increase of concentration of the compound in the blood.

• 日本トキシコロジー学会の論文
• 2000-08-17

著者

• Kitajima Satoshi

  Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health

• Satoh Kanako

  東京都健康安全研究センター 環境保健部

• HIGA Yoshitaka

  Sansho Seiyaku Co., Ltd.

• Yoshino Hiroko

  名古屋市立大学 医学研究科実験病態病理学分野

• Yoshino Hiroko

  Dims Institute Of Medical Science Inc.

• Sai-kato Kimie

  Division Of Toxicology

• Sekita Kiyoshi

  Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences

• Higa Yoshitaka

  Sansho Seiyaku Co. Ltd.

• KARIYA Kimio

  Kobe Gakuin University, Faculty of Pharmaceutical Sciences

• Kariya K

  Kobe Gakuin University Faculty Of Pharmaceutical Sciences

• Kitajima S

  Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health

• OHKUBO Atsushi

  Sansho Seiyaku Co., Ltd.

• KITAJIMA Shunichi

  Panapharm Laboratories Co., Ltd.

• HATORI Akiko

  Institute of Whole Body Metabolism

• Ohkubo Atsushi

  Sansho Seiyaku Co. Ltd.

• Kariya Kimio

  Kobe Gakuin Univ. Fac. Of Pharmaceutical Sciences

• Kitajima Shunichi

  Panapharm Laboratories Co. Ltd.

• Hatori A

  Inst. Whole Body Metabolism Chiba Jpn

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