PREVENTION BY NATURAL FOOD ANTHOCYANINS, PURPLE SWEET POTATO COLOR AND RED CABBAGE COLOR, OF 2-AMINO- 1 -METHYL-6-PHENYLIMIDAZO [4,5 -b] PYRIDINE (PhIP)-ASSOCIATED COLORECTAL CARCINOGENESIS IN RATS INITIATED WITH 1,2-DIMETHYLHYDRAZINE
スポンサーリンク
概要
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The potential of purple sweet potato color (PSPC) and red cabbage color (RCC), natural anthocyanin food colors, to modify colorectal carcinogenesis was investigated in male F344/DuCrj rats, initially treated with 1,2-dimethylhydrazine (DMH) and receiving 2-amino- 1 -methyl-6-phenylim-idazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PSPC and RCC were given at a dietary level of 5.0% in combination with 0.02% PhIP until week 36. No PSPC or RCC-treatment-related changes in clinical signs and body weight were found. Incidences and multiplicities of colorectal adenomas and carcinomas in rats initiated with DMH were clearly increased by PhIP. In contrast, lesion development was suppressed by RCC, or tended to be inhibited by PSPC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci (ACF) by PhIP was significantly decreased by RCC supplementation. The results thus demonstrate that while PhIP clearly exerts promoting effects on DMH-induced colorectal carcinogenesis, these can be reduced by 5.0% PSPC or 5.0% RCC in a diet under the present experimental conditions.
- 2002-02-25
著者
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HAGIWARA Akihiro
DIMS Institute of Medical Science, Inc.
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IMAI Norio
DIMS Institute of Medical Science, Inc.
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Inada Ken-ichi
Department Of Pathology Fujita Health University School Of Medicine
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IMAIDA katsumi
Department of Pathology, Nagoya City University Medical School
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Imai Norio
Dims Institute Of Medical Science Inc.
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Imai Norio
Dims医科学研究所
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Imai N
Department Of Experimental Pathology And Tumor Biology Nagoya City University Medical Sciences
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Hagiwara A
Dims Institute Of Medical Science Inc.
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Hagiwara Akihiro
Dims医科学研究所
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Hagiwara Akihiro
大阪市立大学 医学部病理学第1
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Hagiwara Akihiro
Dims Inst. Medical Sci. Inc.
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KAWABE Mayumi
DIMS Institute of Medical Science, Inc.
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ICHIHARA Toshio
DIMS Institute of Medical Science, Inc.
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IMAIDA Katsumi
Onco-Pathology, Faculty of Medicine, Department of Pathology and Host-Defense, Kagawa University
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KAWABE Mayumi
Daiyu-Kai Institute of Medical Science, Inc.
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ICHIHARA Toshio
Daiyu-Kai Institute of Medical Science, Inc.
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TAMANO Seiko
Daiyu-Kai Institute of Medical Science, Inc.
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HIGA Yoshitaka
Sansho Seiyaku Co., Ltd.
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ITO Nobuyuki
Nagoya City University
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HAGIWARA Akihiro
Daiyu-kai Institute of Medical Science
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YOSHINO Hiroko
Daiyu-kai Institute of Medical Science
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AOKI Hiromitsu
San-Ei Gen F. F. I., Inc
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KODA Takatoshi
San-Ei Gen F. F. I., Inc
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NAKAMURA Mikio
San-Ei Gen F. F. I., Inc
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IMAI NORIO
Daiyu-kai Institute of Medical Science
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Kawabe Mayumi
Dims Inst. Of Medical Sci. Inc.
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Kawabe Mayumi
名古屋市立大学 医学研究科第一病理学
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Kawabe Mayumi
Dims Inst. Medical Sci. Inc.
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Kawabe Mayumi
三省製薬
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Ichihara Toshio
Dims医科学研究所
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Ichihara Toshio
Dims Institute Of Medical Science Inc.
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Ichihara Toshio
Department Of Pathology Osaka City University Medical School
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Ichihara Toshio
大阪市立大学 病理
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Yoshino Hiroko
名古屋市立大学 医学研究科実験病態病理学分野
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Yoshino Hiroko
Dims Institute Of Medical Science Inc.
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Inaguma Shingo
大雄会医科学研究所
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SHIRAI Tomoyuki
First Department of Pathology, Nagoya City University Medical School
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Imaida K
Onco-pathology Faculty Of Medicine Department Of Pathology And Host-defense Kagawa University
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Imaida Katsumi
国立がんセンター研究所 がん予防基礎研究プロジェクト
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Imaida Katsumi
大雄会医科学研究所
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Imaida Katsumi
Department Of Onco-pathology Faculty Of Medicine Kagawa University
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Kuribayashi Masanori
名古屋市立大学 医学研究科実験病態病理学分野
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Inada Ken-ichi
愛知県がんセンター研究所 腫瘍病理学部
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稲田 健一
Department Of Pathology Fujita Health University School Of Medicine
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Higa Yoshitaka
Sansho Seiyaku Co. Ltd.
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Aoki Hiromitsu
San-ei Gen F. F. I. Inc
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Aoki Hiromitsu
San-ei Gen F.f.i. Inc.
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SHIRAI Tomoyuki
Nagoya City University Medical School
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Tamano Seiko
Daiyu-kai Institute Of Medical Science Ichinomiya Japan
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Kawasaki Takeshi
Uchida Wakanyaku Co. Ltd.
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Shirai Tomoyuki
First Department Of Pathology Nagoya City University Medical School
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Ichihara Toshio
Department Of Physics Graduate School Of Science Osaka University
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ITO Nobuyuki
Emeritus Professor. Nagova City University
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Ito Nobuyuki
First Department Of Pathology Nagoya City University Medical School
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Koda T
San-ei Gen F. F. I. Inc
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Koda Takatoshi
San-ei Chemical Industries Ltd.
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Nakamura Mikio
San-ei Gen F. F. I. Inc.
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Hagihara Atsushi
Department Of Pathology Osaka City University Medical School
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Nakamura Mikio
San-ei Gen F. F. I. Inc
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Hagiwara Akihiro
First Department Of Pathology Nagoya City University Medical School
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Ito N
Nagoya City Univ. Nagoya
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Tamano Seiko
Daiyu-kai Institute Of Medical Science
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ICHIHARA Toshio
Daiyu-kai Institute of Medical Science
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